| Project/Area Number |
26893313
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Hiroshima International University |
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Principal Investigator |
HARADA Kana 広島国際大学, 薬学部, 助教 (90609744)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ポリリン酸 / マクロファージ / リポポリサッカライド / IRF3 / STAT1 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the effects of polyphosphate [poly(P)], a drug candidate for the treatment of peri-implantitis, on inflammatory bone resorption-related signal transduction. Poly(P) decreased the initial phosphorylation of STAT1 via suppressing IRF3 phosphorylation in macrophages activated with lipopolysaccharide, a cell wall component of Gram-negative bacteria. In addition, poly(P) was suggested to suppress the delayed phosphorylation of STAT1 in an IRF3-independent manner. These findings provide useful information for the development of novel treatment strategies for peri-implantitis.
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