investigation of mechanism of alveolar bone development and regeneration through analysis of TRPM7, bone mineral transporter.

Research Project

Project/Area Number	26893319
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Dental engineering/Regenerative dentistry
Research Institution	Fukuoka Dental College
Principal Investigator	Tsutsumi Takashi 福岡歯科大学, 歯学部, 助教 (70736652)
Project Period (FY)	2014-08-29 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	歯学
Outline of Final Research Achievements	The main aim of this research is investing the mechanism of alveolar bone development and new bone formation induced by bone regeneration therapy through analysis focused on TRPM7 and generating more effective bone regeneration therapy. TRPM7 is calcium ion and magnesium ion permeable cation ion channel, transports minerals and also contains alpha kinase domain that has various physiological effects. In this research, we estimated the effect of TRPM7 on tibia and alveolar bone properties through in vivo and in vitro experiments using alpha kinase domain mutant mice.