Pharmacological approaches for the suppression of scar formation after palatoplasty in a wound-healing model

Research Project

Project/Area Number	26893320
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Orthodontics/Pediatric dentistry
Research Institution	Fukuoka Dental College
Principal Investigator	Hata Shozaburo 福岡歯科大学, 口腔歯学部, 助教 (40736732)
Project Period (FY)	2014-08-29 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	歯科矯正学 / 創傷治癒 / 筋線維芽細胞
Outline of Final Research Achievements	Scar formation after palatoplasty is considered to inhibit maxillary growth and dento-alveolar development. Transforming growth factor-β1 (TGF-β1) reportedly causes the differentiation of fibroblasts toward cells possessing a contractile phenotype (myofibroblasts) during wound-healing. The aim of this study is to clarify the mechanism underlying the activation of TGF-β1 in efforts to identify promising pharmacological approaches for the suppression of scar formation. As a result, a TGFβ type I receptor inhibitor appears to be effective in inhibiting the myofibroblastic differentiation, and may be a possible therapeutic approach for the suppression of scar formation.

Report

(3 results)