Pharmacological approaches for the suppression of scar formation after palatoplasty in a wound-healing model
| Project/Area Number |
26893320
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
Hata Shozaburo 福岡歯科大学, 口腔歯学部, 助教 (40736732)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯科矯正学 / 創傷治癒 / 筋線維芽細胞 |
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| Outline of Final Research Achievements |
Scar formation after palatoplasty is considered to inhibit maxillary growth and dento-alveolar development. Transforming growth factor-β1 (TGF-β1) reportedly causes the differentiation of fibroblasts toward cells possessing a contractile phenotype (myofibroblasts) during wound-healing. The aim of this study is to clarify the mechanism underlying the activation of TGF-β1 in efforts to identify promising pharmacological approaches for the suppression of scar formation. As a result, a TGFβ type I receptor inhibitor appears to be effective in inhibiting the myofibroblastic differentiation, and may be a possible therapeutic approach for the suppression of scar formation.
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Report
(3 results)
Research Products
(3 results)
