Adipocytokine secretion and redox signaling in obesity-related metabolic diseases

• Project/Area Number: 26893335
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Kansai Medical University (2015); Department of Clinical Research, National Hospital Organization Kyoto Medical Center (2014)
• Principal Investigator: MATSUO Yoshiyuki 関西医科大学, 医学部, 研究員 (50447926)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: タンパク質 / レドックス / 炎症 / アディポサイトカイン / 小胞体 / 分泌

Outline of Final Research Achievements

Accumulating evidence suggests a causal role played by adipose-derived secretory factors, adipocytokines, in the pathogenesis of obesity-related metabolic diseases. We aimed to determine the potential implications of endoplasmic reticulum (ER)-resident folding catalysts in the regulation of adipocytokine secretion. A series of redox enzymes were up-regulated during adipocyte differentiation, suggesting their involvement in adipocytokine synthesis and maturation in the ER. We also found that excessive fat accumulation and lipid peroxidation could induce the expression of thrombospondin 1 (THBS1), a potential mediator of tissue inflammation associated with obesity. Serum THBS1 levels showed a significant correlation with multiple traits of obesity/diabetes in Japanese subjects, particularly in women. THBS1 may act as a critical circulating factor that couples obesity with metabolic syndrome and diabetes in humans.

Research Products

• [Journal Article] Thrombospondin 1 as a novel biological marker of obesity and metabolic syndrome (2015)
  • Author(s): Matsuo Y, Tanaka M, Yamakage H, Sasaki Y, Muranaka K, Hata H, Ikai I, Shimatsu A, Inoue M, Chun TH, Satoh-Asahara N
  • Journal Title: Metabolism Volume: 64 Issue: 11 Pages: 1490-1499
  • DOI: 10.1016/j.metabol.2015.07.016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fatty Acidと心血管疾患 (2014)
  • Author(s): 松尾禎之、浅原（佐藤）哲子、小川佳宏
  • Journal Title: 血管医学 Volume: 15 Pages: 169-177
• [Presentation] 肥満における内臓・皮下脂肪蓄積と線維化関連因子TSP-1との関連解析 (2015)
  • Author(s): 松尾 禎之、田中 将志、佐々木 洋介、山陰 一、村中 和哉、猪飼 伊和夫、畑 啓昭、島津 章、井上 真由美、全 泰和、浅原 哲子
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京第一ホテル下関（山口県）
  • Year and Date: 2015-05-21
• [Presentation] 肥満における内臓・皮下脂肪蓄積と線維化関連因子TSP-1との関連解析 (2015)
  • Author(s): 松尾 禎之、田中 将志、佐々木 洋介、山陰 一、村中 和哉、猪飼 伊和夫、畑 啓昭、島津 章、井上 真由美、全 泰和、浅原 哲子
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: ホテルニューオータニ東京（東京都）
  • Year and Date: 2015-04-23
• [Presentation] Sexually dimorphic, fat depot-dependent expression of a fibrogenic adipokine, thrombospondin 1 (THBS1) in human obesity (2015)
  • Author(s): Noriko Satoh-Asahara, Yoshiyuki Matsuo, Masashi Tanaka, Yousuke Sasaki, Hajime Yamakage, Kazuya Muranaka, Iwao Ikai, Hiroaki Hata, Akira Shimatsu, Mayumi Inoue, Tae-Hwa Chun
  • Organizer: 2015 Keystone Symposia Conference, X7: Obesity and the Metabolic Syndrome: Mitochondria and Energy Expenditure
  • Place of Presentation: Fairmont Chateau Whistler, Whistler, British Columbia
  • Year and Date: 2015-03-22 – 2015-03-27
• [Presentation] 肥満における内臓・皮下脂肪蓄積と線維化関連因子TSP-1との関連性 (2014)
  • Author(s): 松尾禎之、田中将志、佐々木洋介、山陰一、村中和哉、猪飼伊和夫、畑啓昭、島津章、井上真由美、Tae-Hwa Chun、浅原哲子
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: シーガイアコンベンションセンター（宮崎）
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] Sexually dimorphic, fat depot-dependent expression of a fibrogenic adipokine, thrombospondin 1 (THBS1) in human obesity (2014)
  • Author(s): Yoshiyuki Matsuo, Masashi Tanaka, Yousuke Sasaki, Hajime Yamakage, Kazuya Muranaka, Iwao Ikai, Hiroaki Hata, Akira Shimatsu, Mayumi Inoue, Tae-Hwa Chun, Noriko Satoh-Asahara
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress, MSDA2014
  • Place of Presentation: Kyoto International Conference Center, Kyoto
  • Year and Date: 2014-09-12 – 2014-09-14