| Project/Area Number |
58060001
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Research Institution | Faculty of medicine, University of Tokyo |
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Principal Investigator |
ITO Masao Faculty of Medicine, Univ. of Tokyo, Professor, 医学部, 教授 (90009887)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Masahiko Nagasaki Institute of Applied Science, Associate Prof., 助教授 (60103404)
NAGAO Soichi Faculty of Medicine, Univ. of Tokyo, Assistant Prof., 医学部, 助手 (40164397)
SAKURAI Masaki Faculty of Medicine, Univ. of Tokyo, Assistant Prof., 医学部, 助手 (30162340)
MIYASHITA Yasushi Faculty of Medicine, Univ. of Tokyo, Lecturer, 医学部, 講師 (40114673)
福田 潤 東京大学, 医学部, 助教授 (50010062)
FUKUDA Jun Faculty of Medicine, Univ. of Tokyo, Associate Prof.
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| Project Period (FY) |
1983 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥197,000,000 (Direct Cost: ¥197,000,000)
Fiscal Year 1987: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1986: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1985: ¥42,000,000 (Direct Cost: ¥42,000,000)
Fiscal Year 1984: ¥67,000,000 (Direct Cost: ¥67,000,000)
Fiscal Year 1983: ¥62,000,000 (Direct Cost: ¥62,000,000)
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| Keywords | Cerebellum / Long-term depression / Glutamate receptors / Plasticity / Vestibulo-ocular reflex / Motor learning / Pictorial memory neuron / 記憶 / グルタメイト / サッケード |
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| Research Abstract |
This research project has been ailmed at elucidating the long-term depression (LTD) in purkinje cells as a memory process in the cerebellum through studies of its physiological properties and nolecular mechaniams, and also at investigating neuronal mechanisms of motor learning based on the LTD through animal experiments and simulation studies on oculomotor control. Through 5 years from 1983, the project was run by 7 participating researchers and 13 collaborators. The main results obtained were 1) the LTD was established as one of the four major types of synaptic plasticity, 2) Ca^<2+> inflow in purkinje cell dendrites was found to serve as an important step of the LTD, and the desensitization of quisqualate-specific glutamate resptors is the final step of the LTD, 3) the role of the cerebellar flocculus in adaptation of not only vestibulo-ocular reflex but also optokinetic eye movement was establishid, and a general scheme of cerebellar adaptation with the LTD seaving as a memory element was formulated, 4) a model was built to represent cerebellar mechanisms of eye movement control, and successfully subjected to computer simulation. In addition, 5) technigues for control of growth of neurons in tissue culture were developed, and 6) througy comparative study on cognitive learning system, a new group subserving short-term pictorial memory was discovered. These results have been published througy 32 original articles(2 in Nature), 13 proceedings and 2 monographs, and also in 26 international symposia and workshops, 5 congress communications, 32 domestic communications.
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