| Budget Amount *help |
¥21,400,000 (Direct Cost: ¥21,400,000)
Fiscal Year 1985: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1984: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 1983: ¥12,700,000 (Direct Cost: ¥12,700,000)
|
|---|
| Research Abstract |
We found that cadmium health effects appeared when tissue trace elements remarkably elevated or depressed (tissue metal shift) in the preliminary experiment, and thought that the tissue metal shift might play an important role in the mechanism of intoxications from heavy metals such as cadmium, mercury and lead. We performed the following experiments to clarify our hypothesis on rabbits, rats and mice with the use of atomic absorption spectrophotometry and induced coupled plasma emmission spectrophotometry.
1) Tissue metal shift and health effects in a single exposure to geavy metals, (1) tissue metal shift and health effects, (2) biological roles of metallothionein in tissue metal shift, and (3) protective effects of metal pretreatment on radiation health effects and its mechanism.
2) Tissue metal shift and health effects in chronic exposure to heavy metals, (1) doseeffect relationship for cadmium, (2) dose-effect relationship for inorganic mercury, and (3) dose-effect relationship for
… More
inorganic lead.
3) Zinc-deficient acrodermatitis by tissue metal shift (1) lead-induced zinc-deficient acrodermatitis, and (2) cadmium-induced zinc-deficient acrodermatitis.
4) Copper insufficiency or zinc deficiency, factors aggravating chronic toxivities of heavy metals (1) health effexts of copper degiciency, (2) aggravated toxicity of cadmium by copper insufficiency or zinc deficiency, and (3) aggravated toxicity of inorganic mercury by copper insufficiency or zinc deficiency.
5) Preventive and curative effects of copper or zinc supplementation on chronic toxicities of heavy metals (1) preventive effects of copper on cadmium health effects, (2) preventive effects of zinc on inorganic mercury health effects, and (3) curative effects of zinc on inorganic lead health effects.
6) Age-related tissue metal shift, factors aggravating toxicities of heavy metals (1) ageing, a factor aggravating chronic toxicity of cadmium, (2) ageing, a factor aggravating chronic toxicity of inorganic mercury, and (3) ageing, a factor aggravating chronic toxicity of inorganic lead.
The above results indicated (1) exposure to heavy metals, either a single or repeated exposure, induced more remarkable tissue metal shift than expented, (2) lead induced zincdeficient acrodermatitis in rabbits, and (3) copper or zinc supplementation prevented or cured chronic toxicities of cadmium, inorganic mercury and inorganic lead. Less
|
