| Project/Area Number |
58870071
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
AKUTSU Tetsuzo 国立循環器病センター, その他, 研究員 (40150221)
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| Project Period (FY) |
1983 – 1985
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| Project Status |
Completed (Fiscal Year 1985)
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| Budget Amount *help |
¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 1985: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1984: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1983: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | Pusher-plate type TAH / Hall sensor / Optical sensor / Pneumatic control drive system / Motor control drive system / Cylindrical cam / Left-right |
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| Research Abstract |
The overall objective of this research was to develop a pusher-plate type pneumatic total artificial heart system and using the pneumatic system to obtain design criteria for a completely implantable total artificial heart system. The pusher-plate type blood pump was selected because it has excellent controllability and total implantability. The pusher-plate type blood pump consists of a blood side and air side housing between which a polyurethane made diaphragm attached with a pusher-plate is sandwiched. The electro-mechanical or thermal engine can be easily mated with this pump to obtain an implantable system. The pump was designed to fit inside the chest cavity of 50-60Kg goat which is equivalent to body size of Japanese adults. In order to continuously monitor pusher-plate movement, a Hall effect sensor was attached to the air side housing; this signal was then used to derive beat-to-beat pump output and also to precisely regulate pusher-plate movement.Also, an optical sensor was m
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ounted on the blood side housing to continuously monitor blood oxygenation and also to regulate pump output based on the mixed venous oxygen saturation. The pneumatic control drive system was designed to operate the pump in the fill/empty mode utilizing the Hall effect signal. The system also included the option of running left and right pumps in the independently, simultaneously and alternately ejecting mode. To date, this system was implanted in 16 adult goats and 7 calves to show acceptable performance, though long term survivors have not been obtained yet. As for completely implantable system, a motor driven simultaneously ejecting system has been designed based on the in vitro result using the pneumatic system. It consists of a DC-brushless motor sandwiched between two ventricles and a cylindrical cam-double cam follower to covert the rotational motion of the motor to recti-linear motion, thus to push on the pusher-plate of the blood pumps. The system has been fabricated and being bench tested. Less
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