| Project/Area Number |
58870074
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
NISHIMOTO Akira OKAYAMA UNIVERSITY MEDICAL SCHOOL,PROFESSOR, 医学部, 教授 (50032850)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Takashi OKAYAMA UNIVERSITY HOSPITAL SENIOR PRESIDENT, 医学部・附属病院, 医員
MORIYA Yosio OKAYAMA UNIVERSITY HOSPITAL SENIOR PRESIDENT, 医学部・附属病院, 医員
NAKASONE Susumu OKAYAMA UNIVERSITY HOSPITAL SENIOR PRESIDENT, 医学部・附属病院, 医員
MATSUMOTO Kengo OKAYAMA UNIVERSITY HOSPITAL SENIOR PRESIDENT, 医学部・附属病院, 医員
TABUCHI Kazuo OKAYAMA UNIVERSITY MEDICAL SCHOOL,INSTRUCTOR, 医学部, 講師 (50116480)
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| Project Period (FY) |
1983 – 1985
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| Project Status |
Completed (Fiscal Year 1985)
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| Budget Amount *help |
¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 1985: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1984: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1983: ¥10,000,000 (Direct Cost: ¥10,000,000)
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| Keywords | SUPER ULTRSHORT WAVE / DIFFERNTIAL HYPOTHERMIA / BRAIN TUMOR / 実験脳腫瘍 / 局所脳血流量 / 脳腫瘍 / ACNU / マイクロウエーブ / 温熱化学療法 |
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| Research Abstract |
Developing of system of super ultrashortwave irradiation and measurement of temperature using differential hypothermia treatment of malignant brain tumor
1. we studied the activity of heating by the using of the 2451MHz microwave irradiation system with establishment of objective heeting temperature and automatic control of output device and non contact applicator. 1) phantom : we performed iraddiating that applicator was 7cm away from it we can heat it 20cm diameter & 20mm depth. 2) differential hypothermia treatment was performed by 10 normal monkey brians. we can heat white matter 4cm diameter & 10mm depth from the brain surface at the degree of 37ﾟC.
2. we measured regional cerebral blood flow of the white matter 10mm depth from the brain surface by the inhalation hydrogen clearance method for physiological basis at the differential hypothermia treatment. we had the result that when heat it at the degree of 37ﾟC regional cerebral blood flow increased about two hold compared with befo
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re heating. And after the heating regional cerebral blood flow came back to before heating.
3. we performed differential hypothermia treatment to 10 virally induced monkey brain tumors. The brain of performed side was revealed edema at centering around the brain surface immediately the treatment, but after 24hours edema was extinguished. Follow up-CT was performed to the 5,3 were revealed the decreasing the tumor size, but 1 was revealed the increasing the tumor size.
4. We examined the effect of differential hypothermia treatment influence of strength of ACNU in the blood & tissue of brain. method : 1) control ; ACNU (20mg/body) was prescrived (iv) in the general anethsezia and at norotemperature, and drew the blood 2) differntial hypothermia treatment ; After 1 week ago, we performed bilateral craniectomy and heating to the one side brain of the same monkey by the 245GHz microwave irradiation system with automatic control of establishment temperature and applicator of non touch, and keep the temperature (37-40ﾟC) and after prescriving ACNU drew the blood and brain tissue (heeting side, non heeting side) 3) measurement concentration of ACNU : we freezed it immediatry, and measured concetration of ACNU by HPLC and analised pharmacokinetics. result : 1) a half period of ACNU (in the blood) in the differential hypothermia treatment was extended two hold compared with contorol in the normal temperature. 2) there was no differeciation that absolute value of concentration of ACNU in the tissue of the brain among the heeting side and non heeting side, but extending of a half period of ACNU of the heeting side was revealed by the analysis of one compartment open model. conclusion : by the differential hypothermia treatment concetration of ACNU in the blood was keeped high volume compare with in the normal temperature cause of metabolism and excrtio of the ninternal organs was delaid. further for that was metabolized and taken apart to pieces speed of nearly of normal temperature on the heeting side, we consider that combine therapy of two will acquire the increasing effect of antitumor Less
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