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Molecular Mechanism of Steroid Hormone Action and Modulation of Gene Expression

Research Project

Project/Area Number 59370011
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionOsaka University

Principal Investigator

SAKAMOTO Yukiya  Osaka Univ., Medical School, Professor, 医学部, 教授 (60028280)

Co-Investigator(Kenkyū-buntansha) ENDO Hiroyoshi  Teikyo Univ., Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (50012604)
村山 昭  東京都臨床医学総合研究所, 主任研究員 (10109952)
OTA Minoru  Iwate Medical Univ., School of Dentistry, Professor, 歯学部, 教授 (70048255)
ICHIHARA Akira (MURAYAMA Akira)  Univ. of Tokushima, School of Medicine, Professor, 医学部, 教授 (40035374)
ICHII Shogo  Tottori Univ., School of Medicine, Professor, 医学部, 教授 (80032150)
Project Period (FY) 1984 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥16,000,000 (Direct Cost: ¥16,000,000)
Fiscal Year 1986: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1985: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1984: ¥7,000,000 (Direct Cost: ¥7,000,000)
KeywordsSteroid Hormone Receptor / Glucocorticoid / Testosterone / Estrogen / Progesterone
Research Abstract

An intensification in the study of steroid hormone receptors and their molecular mechanisms of aciton has resulted in a great deal of information on how the steroid hormones stimulate cells by controlling the synthesis of particular protein. However, the primary structure of the steroid hormone receptors and their subunits, and the modulators or receptor functions, and regulation of gene expression have not previously been elucidated. Thus, this research project was organized to further the understanding and elucidation of the molecular mechanism of steroid hormone action which underlies the physiological process.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Yamamoto,A.: Endocrinology. 119. 357-361 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nakamura,T.: Proc.Natl.Acad.Sci.USA. 83. 6489-6493 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nawa,K.: J.Biol.Chem.261. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nakamura,T.: J.Biol.Chem.262. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nakamura,T.: Exp.Cell Res.(1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Matuo,Y.: Cancer Research. 47. 188-192 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Isohashi,F.: "Glucocorticoid Hormone-Mechanisms of Action" Japan Scientic Press Tokyo and Springer Verlag Berlin Heidelburg,New York,Tokyo, 25 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 市原明: "続生化学実験講座" 東京化学同人, 10 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yamamoto, A.: "Change in activity of ATP-stimulated glucocorticoid receptor translocaiton promoter in the cytosol and nucleus of rat liver under various physiological conditions" Endocrinology. 119. 357-361 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nakamura, T.: "Purification and characterization of hepatocyte growth factor" Proc. Natl. Acad. Sci. USA. 83. 6489-6493 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nawa, K.: "Glucocorticoid-dependent expression of the albumin gene in adult rat hepatocytes" J. Biol. Chem.261. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Nakamura, T.: "Multi-hormonal regulation of the tryptophan 2,3-dioxygenase gene in primary cultures of adult rat hepatocytes mediating the action of glucocorticoids" J. Biol. Chem.262. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Matuo, Y.: "Heparin binding affinity of rat prostatic growth factor in normal and cancerous prostates" Cancer Research. 47. 188-192 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Isohashi, F.: Japan Scientic Press Tokyo and Springer Verlag Berlin Heidelburg, New York, Tokyo. Translocation or Binding of Activated Receptor-Glucocorticoid Complex to Nuclear Acceptors; Identification and Mechanism of Possible Regulatory Substances, 34-69 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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