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STUDIES ON PROTECTION AND CONTROL OF EPIDEMIC HEMORRHAGIC FEVER (EHF) IN LABORATORY ANIAML EXPERIMENTATION

Research Project

Project/Area Number 59380005
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionRESEARCH INSTITUTE FOR MICROBIAL DISEASES, OSAKA UNIVERSITY

Principal Investigator

YAMANOUCHI TAKAHISA  RESEARCH INSTITUTE FOR MICROBIAL DISEASES, OSAKA UNIVERSITY, Professor, 微生物病研究所, 教授 (40029765)

Co-Investigator(Kenkyū-buntansha) HAMADA CHUYA  MEDIAL FACULTY OF NIIGATA UNIVERSITY, Professor, 医学部, 教授 (40027313)
KURATA TAKESHI  NATIONAL INSTITUTE OF HEALTH, JAPAN, Head of Department, 部長 (50012779)
MORIMOTO YASUHIKO  MEDICAL FACULTY OF OSAKA UNIVERSITY, Associate Professor, 医学部, 助教授 (00028424)
DOMAE KAYOKO  as above, Research Associate, 微生物病研究所, 助手 (80127266)
YAMANISHI KOICHI  as above, Associate Professor, 微生物病研究所, 助教授 (10029811)
Project Period (FY) 1984 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥17,400,000 (Direct Cost: ¥17,400,000)
Fiscal Year 1986: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1985: ¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1984: ¥6,400,000 (Direct Cost: ¥6,400,000)
KeywordsEpidemic Hemorrhagic Fever / Hemorrhagic Fever with Renal Syndrome / HFRS Virus / Laboratory Animals / ラット
Research Abstract

Two cases of laboratory type HFRS (EHF) were recorded in 1984 in Japan. Thereafter, we have no new patient reported. Every year, we have written annual report of our group-research and the guide-lines for protection and diagnosis of laboratory type infection of HFRS issued by the Ministry of Education, Science and Culture, Japan. We delivered them to all biomedical institutions in Japan. These measures increased the level of understanding of HFRS by biomedical researchers and people working in the animal facilities. As the results, the number of HFRS patients decreased. Most of the cases of the HFRS reported in Japan were caused by viral infection from contaminated laboratory rats. Newborn mice and newborn rats were experimentally infected with viral strains isolated from rats and stripe field mouse. Comparison of the mortality among the infected animals and the recovery of the infective viruses from various organs of them indicates that the animals are more susceptible to the virus st … More rains derived from the animals lelonging to the same genus than those from the animals belonging to the different genus. HFRS viruses are classified as a Bunya virus and devided into four subtypes according to animal species from which they were isolated. Immunological difference of these subtypes was found by using the specific monoclonal antibodies prepared against each viral strain. Electronmicroscopy demonstrated that the HFRS viral particle had a lattice-like surface structure, and some viral particles of certain strains derived from rats had a tail-like structure. Virus strains derived from rats could infect adult rats, resulting in persistnce in several organs. Persistence of the virus in the brain of the infected rats was observed for more than eight months. On the basis of the pathological observation that the virus sometimes caused inflamation of blood vessels, the HFRS might be classified as a "Blood Vessel Disease." Clinical and serological examinations of a HFRS patient was carried out during the hospitalization period. These examinations provided valuable informations for clinical diagnosis. Studies on the low-titre seropositive aniamls and the modes of transmission among experimental animals are to be carried out. Less

Report

(1 results)
  • 1986 Final Research Report Summary

Research Products

(14 results)

All Other

All Publications

  • [Publications] YAMANOUCHI,T.ET AL.,: MICROBIOLOGY & IMMUNOLOGY. 28. 1345-1353 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] YAMANISHI,K.,ET AL.,: JOURNAL OF VIROLOGY. 52. 231-237 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] HAMADA,C.,ET AL.,: EXPERIMENTAL ANIMALS. 35. 1-10 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] DANTAS,J.R.Jr.,ET AL.,: VIROLOGY. 151. 379-385 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 森本靖彦: 感染症学雑誌. 60. 322-335 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 有川二郎: ウイルス. 36. 233-251 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 川俣順一: "腎症候性出血熱(流行性出血熱)の感染と予防(動物実験に関連して)" 医歯薬出版社, (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] YAMANOUCHI, TAKAHISA, ET AL.,: "EXPERIMENTAL INFECTION IN NEWBORN MICE AND RATS BY HEMORRHAGIC FEVER WITH RENAL SYNDROME (HFRS) VARUS" MICROBIOLOGY & IMMUNOLOGY. 28. 1345-1353 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] YAMANISHI, KOICHI, ET AL.,: "ANTIGENIC DIFFERENCES BETWEEN TWO VIRUSES, ISOLATED IN JAPAN AND KOREA, THAT CAUSE HEMORRHAGIC FEVER WITH RENAL SYNDROME" JOURNAL OF VIROLOGY. 52. 231-237 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] HAMADA, CHUYA, ET AL.,: "AN ATTEMPT TO IMPROVE THE IMMUNOFLUORECENT ANTIBODY TECHNIQUE FOR HEMORRHAGIC FEVER WITH RENAL SYNDROME" EXPERIMENTAL ANIMALS. 35. 1-10 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] MORIMOTO, YASUHIKO,: "CLINICAL FEATURES, LABORATORY DATA AND ANTI-VIRAL ANTIBODY IN A SEVERE CASE OF HEMORRHAGIC FEVER WITH RENAL SYNDROME (HFRS) -A ONE-MONTH COUSE FROM ONSET" KANSENSHOGAKU ZASSHI (In Japanese). 60. 322-335 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] ARIKAWA, JIRO,: "HEMORRHAGIC FEVER WITH RENAL SYNDROME" VIRUS (In Japanese). 36. 233-251 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] DANTAS, JOSE, R. Jr., ET AL.,: "CHARACTERIZATION OF GLYCOPROTEINS OF VIRUSES CAUSING HEMORRHAGIC FEVER WITH RENAL SYNDROME (HFRS) USING MONOCLONAL ANTIBODIES" VIROLOGY. 151. 379-385 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] KAWAMATA, JUNICHI,: I-SHI-YAKU SHUPPANSHA. PROTECTION AND CONTROL OF HEMORRHAGIC FEVER WITH RENAL SYNDROME (EPIDEMIC HEMORRHAGIC FEVER) IN LABORATORY ANIMAL EXPERIMENTATION (In Japanese), (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-30   Modified: 2016-04-21  

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