| Project/Area Number |
59430016
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
有機工業化学
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| Research Institution | Institute of Industrial Science, University of Tokyo |
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Principal Investigator |
URYU Toshiyuki Institute of Industrial Science, University of Tokyo, 生産技術研究所, 教授 (80011005)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Shojiro Faculty of Home Economics, Ochanomizu University, 家政学部, 助教授 (20013196)
SHIRAISHI Shinsaku Institute of Industrial Science, University of Tokyo, 生産技術研究所, 教授 (30013163)
SENO Manabu Institute of Industrial Science, University of Tokyo, 生産技術研究所, 教授 (40013099)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥35,000,000 (Direct Cost: ¥35,000,000)
Fiscal Year 1986: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1985: ¥9,500,000 (Direct Cost: ¥9,500,000)
Fiscal Year 1984: ¥24,500,000 (Direct Cost: ¥24,500,000)
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| Keywords | Heparinoid / Anticoagulant activity / High performance liquid chromatography / Chloromethylated polystyrene beads / Polymer liquid crystal / Aromatic polyester / Solid state CP / 固体高分解能CP・MAS【_(13)C】NMR / 多糖グラフト高分子 / 多糖マクロマー / t-ブチルジメチルシリル / 合成高分子グラフト多糖 / NMR / アルキル置換ポリスチレンゲル |
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| Research Abstract |
Dextran-type polysaccharides containing sulfamide and sulfate groups at regio-selective positions were synthesized by a series of reactions starting from the ring-opening polymerization of 1,6-anhydro-azido sugars. The sulfamide group exhibted almost the same anticoagulant activity as that of the sulfate group, and the former had a function to decrease the acute toxicity <LD_(50)> . 1,5- <alpha> -Linked furanan-type polysaccharides which were prepared by the ring-opening polymerization of 1,4-anhydro-ribose and -xylose were sulfated to give sulfated furanan-type polysaccharides. These heparinoids showed the highest anticoagulant activity of the so-far prepared heparinoids. The structure analysis of synthetic polysaccharides and sulfated ones was performed by using ordinary NMR and 2D NMR spectroscopy as well as the elemental analysis, indicating the position of sulfate group.
Chloromethylated polystyrene beads were reacted with various alkylamines to provide the stationary phase of high
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perfomance liquid chromatography. The obtained chloromethylated polystyrene beads can be used in a wide pH range. In addition, the selective separation of halobenzenes and alkylbenzenes was possible by properly choosing the alkyl chain length, for example, by using a <C_(14)> stationary phase. Functionalization of crosslinked poly(chloromethylstyrene) beads was carried out by the reaction with sodium nitrite in the presence of phase transfer catalyst to afford the beads having carboxyl and hydroxyl groups.
Thermotropic aromatic polyesters and low-molecular-weight model compounds were synthesized. They consisted of aromatic mesogens and flexible alkylene spacers. The structure of aromatic polyesters most of which were hardly soluble in solvents were analyzed with solid state CP/MAS <^(13)C> NMR spectroscopy. In the polyester prepared at low temperature, the alkoxy group bonded to the aromatic ring had a fixed orientation, which provides a guide to the molecular design of liquid crystalline polymers with excellent mechanical properties. Less
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