| Co-Investigator(Kenkyū-buntansha) |
ITO Tadaatsu Teikyo University School of Medicine, 医学部, 講師 (10151515)
YOSHINO Katsuya Teikyo University School of Medicine, 医学部, 講師 (70091064)
ABE Toshiaki Teikyo University School of Medicine, 医学部, 助教授 (40101117)
KIDA Mitsushiro Teikyo Women's Junior College, 教授 (50082160)
SHINOZAKI Tatsuhiko Teikyo University School of Law, 法学部, 教授 (10101718)
|
|---|
| Budget Amount *help |
¥18,500,000 (Direct Cost: ¥18,500,000)
Fiscal Year 1986: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1985: ¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1984: ¥10,000,000 (Direct Cost: ¥10,000,000)
|
|---|
| Research Abstract |
I considered that the most effective way of securing Japan's future productive population would be to establish effective countermeasures against infections by clarifying onset mechanisms of still unsolved infections, with complete control of infections in infants, especially those in newborn, premature and sucking infants as the ultimate goal. We devoted 3 years to comprehensive and exhaustive studies in this field, with full cooperation of experts at various research groups of our department specializing in bacterial and viral infections, chemotherapy, immunology, neonatology, onchology, bone marrow transplantations, neurology, biochemistry, human genetics, etc. We had conducted national seuveys on the actual situation of child septicemia and bacterial meningitis as the basis for these studies and obtained guiding principles for future improvements in these diseases from etiological, epidemiological and chemotherapeutic standpoints. In viral diseases, we studies diagnostic methods fo
… More
r rotaviral infections, clarified their annual prevalences at medical institutes or in nurscries, and obtained basic data on effective countermeasures against these infections through analysis of their prevalences even by their sub-types. We could clarify the actual situation and significances of secondary bacterial infections accompanying respiratory infection, including those by Respiratory Syncytial Viruses.
We conducted national surveys also on viral encephalitis and meningitis in infants, analyzed pathogenic factors genetically or in light of developmental immunology and discovered that the effects of immunological mechanisms in premature infants remained even in the sucking stage of development. New findings on onset mechanisms of infections were obtained in infantile diarrhea and viral infections. Sub-types of human macrophage producing IL-1 were clarified in the studies of its activity. Various other new findings were also obtained on assay and diagnostic methods, as for ezample, the introduction of molecular epidemiological studies of rotaviruses and intestinal adenoviruses and the use of nasal wash methods for determining causative agents in respiratory infections. As the studies covered a wide range of special fields, we could not describe here all of them. Consequently, pathogenic factors for serious infection, non-serious but high incidence acute respiratory tract infections and diarrhea in infants were analyzed and the significances of there factors in hospital infections were clarified with reference to their onset mechanisms. In addition, through analysis of patholigical conditions in these infections, we could improve their diagnostic techniques and precisions. In the therapeutic field, the significance of single antimictobial treatment was insisted and at the sametime theoretical grounds for combination therapy were newly presented. It was clarified that the future directions and involved problems along with the study subject. Less
|
