Development of imaging methods of ischemic heart disease by labeled antimyosin using NMR and SPECT
| Project/Area Number |
59440050
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | University of Tokyo |
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Principal Investigator |
IIO Masahiro Faculty of Medicine, University of Tokyo, Professor, 医学部(病), 教授 (80143486)
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| Co-Investigator(Kenkyū-buntansha) |
YAZAKI Yoshio Faculty of Medicine,University of Tokyo,Instructor, 医学部(病), 講師 (20101090)
OHTAKE Tohru Faculty of Medicine,University of Tokyo, 医学部(病), 助手 (80152164)
YOSHIKAWA Hohki Faculty of Medicine,University of Tokyo,Instructor, 医学部(病), 講師 (40114714)
NISHIKAWA Junichi Faculty of Medicine,University of Tokyo,Assistant Professor, 医学部(分), 助教授 (00010322)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥12,500,000 (Direct Cost: ¥12,500,000)
Fiscal Year 1986: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1985: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1984: ¥6,500,000 (Direct Cost: ¥6,500,000)
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| Keywords | Ischemic cardiac diseases / MRI / Gd-DTPA / Gd labeled antimyosin monoclonal antibody / Gd標識抗ミオシン重鎖 / モノクローナル抗体 / ^<111>In標識抗ミオシン重鎖モノクローナル抗体 / Gd標識抗ミオシン抗体 / Gd-DTPA |
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| Research Abstract |
We have evaluated the usefulness of MRI ( magnetic resonance imaging ) for the diagnosis of the ischemic cardiac diseases by using superconductive MR machine. Our study in 1984 revealed that the fresh myocardial infarction (MI ) could be differentiated from old MI on MRI. Our result in 1985 was that the more the patient had severely infarcted myocardium, the longer the abnormatity was noted on MRI, so we could forecast the prognosis of the patients with MI by MRI. Since 1985, we have been tring to waluate the contrast materials for MRI to examine the possibility of more precise characterization of the myocardium. Gadolinium labeled antimyosin antibody was revealed to be accumulated in MI by measuring the content of Gd in the infarcted myocardium and normal myocardium in 1985, but it was not until 1986 that the accumulation of Gd labeled antimyosin antibody in the infarcted myocardium could be detected by MRI. in 1986, our study revealed that the most suitable time of imaging of MRI was 40 - 120 min. after intravenous injection of Gd labeled antibody. This was the advantage of MRI to NM study which needed 24 hours from injection of antibody before imaging.
Another main subject of our study is SPECT for the diagnosis of the ischemic cardiac diseases. We were evaluating In-111 labeled antimyosin antibody for the radiopharmaceutical of detection of the experimental MI. This In-111 labeled antibody revealed to be accumulated in MI for 3 weeks after making experimental MI. Our study also documented that the size of the accumulation of In-111 labeled antibody was more precisely correlated to the actual size of MI than that of Tc-99m -PYP, which was widely accepted for the infarction avid material.
These results convinced us that the labeled antimyosin antbody was the suitable contrast material for the detection of MI and offered us many useful informations for the care of the patients with MI.
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Report
(3 results)
Research Products
(10 results)
