| Project/Area Number |
59440052
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | School of Medicine, University of Tokyo |
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Principal Investigator |
OGATA Etsuro Professor, School of Medicine, University of Tokyo, 医学部, 教授 (70013761)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Naohide Assistant Professor, School of Medicine, University of Tokyo, 医学部(分), 助手 (90174680)
MATSUMOTO Toshio Assistant Professor, School of Medicine, University of Tokyo, 医学部(分), 助手 (20157374)
IGARASHI Tetsuya Assistant Professor, School of Medicine, University of Tokyo, 医学部(分), 助手 (00134601)
YAMAMOTO Michiko Assistant Professor, School of Medicine, University of Tokyo, 医学部(分), 助手 (60150281)
KUROKAWA Kiyoshi Associate Professor, School of Medicine, University of Tokyo, 医学部(分), 助教授 (30167390)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥28,000,000 (Direct Cost: ¥28,000,000)
Fiscal Year 1986: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1985: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1984: ¥18,000,000 (Direct Cost: ¥18,000,000)
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| Keywords | calcium / phosphorus / PTH / vitamin D / calcitonin / 偽性副甲状腺機能低下症 / 骨 / 腎 |
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| Research Abstract |
(1) Criteria of Ellsworth-Howard test: We established the criteria of Ellsworth-Howard test using 1-34 human PHT. These criteria are now widely used in Japan. (2) Investigation of PTH-resistance in peudohypoparathyroidism: We revealed that PTH-resistance is due to the lack of action of 1,25 <(OH)_2> <D_3> and application of 1,25 <(OH)_2> <D_3> to psedohypoparathyroidism :can control the abnormalities of calcium metabolism. (3) Clinical investigations of calcium metabolism in myotonic dystrophy, Cushing syndrome and malignancies: We investigated the calcium and phosphate metabolism in these diseases and carried out therapeutic trials. (4) Calcium metabolism in OPLL: It was revealed that the lack of 1,25 <(OH)_2> <D_3> action may participate in its exacerbation. (5) Perfusion balance studies in rat: We clarified renal reabsorption of calcium is facilitated by vitamin D and vitamin D enhances the action of PTH. (6) Renal action of calcitonin: It was revealed that calcitonin exerts its action independent of cAMP and is affected by prostaglandin <E_2> . (7) Adaptation mechanism of phosphorus deprivation: Using streptozotocin-induced diabetic rats, we demonstrated that insulin is directly or indirectly involved in this adaptation. In addition, the activation renal 1 <alpha> -hydroxylase is facilitated by insulin. (8) Studies on osteoblast-like cells: It was revealed that phosphatidylserine in matrix vesicle membrane forms Ca-PS-P complex, which may be important in the early step of calcification. (9) Studies on PTH gene: We identified the DNA area which mediates 1,25 <(OH)_2> <D_3> action. We could also identify the area which is necessary for PTH gene expression.
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