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Studies on Impurity, Decomposition and Biotransformation of Volatile Anesthetics

Research Project

Project/Area Number 59440065
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

MORIO Michio  Hiroshima University School of Medicine, Proffessor, 医学部, 教授 (80033950)

Co-Investigator(Kenkyū-buntansha) FUJII Kohyu  Hiroshima University School of Medicine, Assistant Professor, 医学部, 助手 (60034021)
ISHIHARA Shin  Hiroshima University University Medical Hospital, Associate Proffessor, 医学部附属病院, 講師 (00106808)
YUGE Osafumi  Hiroshima University University Medical Hospital, Associate Proffessor, 医学部附属病院, 講師 (40034128)
KIKUCHI Hirosato  Hiroshima University School of Medicine, Associate Proffessor, 医学部, 助教授 (40034029)
Project Period (FY) 1984 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥19,500,000)
Fiscal Year 1986: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1985: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1984: ¥17,000,000 (Direct Cost: ¥17,000,000)
KeywordsVolatile Anesthetic / Isoflurane Sevoflurane / Sodalime / Decomposition / セボフルレン / ソーダライム / ハロセン / トリフルオロ酢酸 / フッ素イオン / 不純物
Research Abstract

Sevoflurane and isoflurane are newly developed volatile anesthetics. We studied on the stability of these anesthetics with sodalime and an extent of their biotransformation.
1. Isoflurane, sevoflurane, halothane, methoxyflurane, and enflurane were stable under ultra-violet-ray exposure for two years.
2. Trifluoroacetic acid was detected in the bile of rabbits and rats during and after inhalation of halothane by ionchromatography. Unlike <CF_2> CHCl and <CF_3> <CH_2> Cl, anearobic metabolites of halothane, the excretion of trifluoroacetic acid remained unchanged at each concentration of halothane.
3. Trifluoroacetic acid was detected in the bile of rabbits during and after inhalation of isoflurane by ionchromatography. The excretion of trifluoroacetic acid increased dose dependently.
4. The inorganic fluoride increased dose relatedly and approximately im mol was excreted after 1 MAC x hour inhalation of isoflurane.
5. The half-lives of inorganic and organic fluoride as metabolites of isoflurane in man was calculated to be 29 and 39 hours, respectivery.
6. The half-life of inorganic fluoride as metabolites of sevoflurane in man was calculated to be 34 hours.
7. Sevoflurane reacted with sodalime to produce 5 degraded products. These products were a dehydrofluorinated sevoflurane, its methylated product and 3 kinds of dehydrofluorinated products of the methylated product.

Report

(2 results)
  • 1986 Final Research Report Summary
  • 1985 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 藤井宏融: 麻酔と蘚生,21(別冊)5〜8. 21(別). 5-8 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 藤井宏融: 麻酔と蘚生. 21(別). 7-10 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Reiko Takiyama: Hiroshima J. of Medical Sciences. 34. 377-380 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 盛生倫夫: 病態生理. 5. 157-160 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 藤井宏融: 麻酔と蘚生. 22(別). 47-51 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Motoichi Okida: Hiroshima J. of Medical Sciences. 35. 15-20 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Chihiro Hanaki: Hiroshima J. of Medical Sciences. 36. 61-67 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kohyu Fujii: Hiroshima J. of Medical Sciences. 36. 89-92 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hirosato Kikuchi: Hiroshima J. of Medical Sciences. 36. 93-97 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Tatiana Ivanova Davidkova: Hiroshima J. of Medical Sciences. 36. 99-104 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kohyu Fujii: "A New Apprication in Trifluoroacetic Acid Analysis" Hiroshima J. of Anesthesia. 20 (s). 5-8 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kohyu Fujii: "Studies on Isoflurane Metabolism" Hiroshima J. of Anesthesia. 21 (s). 7-10 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Reiko Takiyama: "Clinical Effects of Halothane Concentration on Trifluoroacetic Acid Excretion in Urine" Hiroshima J. of Medical Sciences. 34. 377-380 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Michi Morio: "Biotranceformation of Inhalational Anesthetics" Medicina Philosophica. 5. 157-160 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kohyu Fujii: "Excretion of a Glucuronide in Bile as a Sevoflurane Metabilite during Sevoflurane Anesthesia" Hiroshima J. of Anesthesia. 22(s). 47-51 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Motoichi Okida: "Concentration-Dependence of Halothane Metabolism in Rabbits" Hiroshima J. of Medical Sciences. 35. 15-20 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Chihiro Hamaki: "Decomposition of Sevoflurane by Sodalime" Hiroshima J. of Medical Sciences. 36. 61-67 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kohyu Fujii: "Pharmacokinetic Study on Excretion of Inorganic Fluoride Ion, a Metabolite of Sevoflurane" Hiroshima J. of Medical Sciences. 36. 89-92 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hirosato Kikuchi: "Clinical Evaluation and Metabolism of Sevoflurane in Patients" Hiroshima J. of Medical Sciences. 36. 93-97 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Tatiana Ivanova Davidkova: "Urinaly Excretion of Inorganic and Organic Fluoride after Inhalation of Sevoflurane" Hiroshima J. of Medical Sciences. 36. 99-104 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 麻酔と蘇生. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] Hiroshima Journal of Medical Science. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] Hiroshima Journal of Medical Science. (1986)

    • Related Report
      1985 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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