| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kaoru School of Medicine Keio University, 医学部, 助手 (10146673)
DEGUCHI Nobuhiro School of Medicine Keio University, 医学部, 講師 (90118977)
BABA Shiro School of Medicine Keio University, 医学部, 講師 (00051889)
JITSUKAWA Seido School of Medicine Keio University, 医学部, 助教授 (00101957)
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| Budget Amount *help |
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 1986: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1985: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1984: ¥8,500,000 (Direct Cost: ¥8,500,000)
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| Research Abstract |
TBSN-2, a monoclonal antibody derived from a cultured cell line of bladder origin, KU-1, showed high cytotoxicity against cultured cell-lines derived from bladder tumors and fresh surgical specimens of bladder tumors as well. Also noted was increased cytotoxicity by the monoclonal antibody in the presence of compliments (Sasaki, Keio J. Med. 33, 1984). ARC-1, a monoclonal antibody derived from a cultured cell-line of renal origin, KU-2, showed cytotoxicity against different tumor cells of different renal tumors. The heterogeneity regarding immunological characteristics was shown to be present in different clones of KU-2 (Nakamura, Keio J. Med. 35, 1986). Various interferons ( <alpha> , <beta> , <gamma> )had an inhibitory effect upon growth of cultured cell of renal and prostatic tumor origin, and NK activity was thought to contribute to the inhibitory effect (Marumo, Keio J. Med. 33, 1984). Furthermore, tumoricidal effect by these interferons was shown to increase by preincubation of t
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he effector cells, and recycling of NK cells was suggested (Marumo, Keio J. Med. 33, 1984). Another known immunopotentiator, BCG, was shown to exhibit both cytolytic and cytostatic effect upon ulture cells of bladder origin mediated by macrophages (Nakamura, Keio J. Med. 33, 1984). Assessment of an immunological profile determined by quantification of serum cytokines showed an increased-level of TNF in patients with renal cell and prostatic tumors (Nakajima, Jap. Canc. So. 1986). When the correlation between biological grades of tumors and intranuclear DNA contents of these tumors was examined, undifferentiated tumors showed marked abnormality in this regard. Therefore determination of DNA-contents was thought to be useful to predict the growth or metastatic potential of tumors (Tachibana, Jap. J. Urology, 77, 1986). These results indicated that factors related to the environment in cancer-bearing host could be a determinant in the proliferation of tumors, and also because of the presence of clonal heterogeity existing in a given tumor. Less
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