| Project/Area Number |
59440069
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Tokyo |
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Principal Investigator |
MASAHIKO MIZUNO Dept. of Ob/Gyn, Faculty of Medicine, Univ. of Tokyo, 医学部(産婦人科), 教授 (10010175)
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| Co-Investigator(Kenkyū-buntansha) |
上妻 志郎 東京大学, 医学部(産婦人科), 助手 (30143457)
岡井 崇 東京大学, 医学部(産婦人科), 講師 (40126016)
YOSHINORI KUWABARA Dept. of Ob/Gyn, Faculty of Medicine, Univ. of Tokyo, 医学部(産婦人科), 助教授 (20010324)
SHIRO Kozuma Dept. of Ob/Gyn, Faculty of Medicine, Univ. of Tokyo
TAKASHI OKAI Dept. of Ob/Gyn, Faculty of Medicine, Univ. of Tokyo
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥23,000,000 (Direct Cost: ¥23,000,000)
Fiscal Year 1986: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1985: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 1984: ¥11,000,000 (Direct Cost: ¥11,000,000)
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| Keywords | Fetal physilogy / Perinatal medicine / Extrauterine Fetal Incubation / Fetal electroencephalogram / 人工子宮 / 胎外哺育 / エクモ / 人工肺 |
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| Research Abstract |
Despite the recent progress of research methods, it is still difficult to analyze fetal behaviors and functions. in order to obtain more direct informations from a fetus, this new extrauterine incubation system has been developed by using 40 goat fetuses. The fetus is surrounded by artificial amniotic fluid and connected with the extracorporeal membrane oxygenator. The blood is drained from the umbilical arteries and returned to the umbilical vein. Several parameters are continuously recorded by the polygraph to monitor the fetal conditions. The fetuses could keep fairly physiological and stable conditions for a considerable period which ranged up to 10 days. It is considered that this system can be a useful method to investigate fetal pathophysiology. In fact, several researches have been undertaken to investigate the development of fetal central nerve system, the fetal behaviours, the fetal water metabolism and the fetal carbohydrats metabolism. It was elucidated by the analysis of fetal electroencephlogram that a fetus obtains the own biorhythm of the central nerve system around 120 days of fetal age.
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