Development of experimental animals by introduced foreign DNA

Research Project

Project/Area Number	59442001
Research Category	Grant-in-Aid for General Scientific Research (A)
Allocation Type	Single-year Grants
Research Field	Laboratory animal science
Research Institution	Central Institute for Experimental Animals
Principal Investigator	NOMURA Tatsuji (財)実験動物中央研究所, その他, その他 (10072399)
Project Period (FY)	1984 – 1985
Project Status	Completed (Fiscal Year 1985)
Budget Amount *help	¥14,000,000 (Direct Cost: ¥14,000,000) Fiscal Year 1985: ¥7,000,000 (Direct Cost: ¥7,000,000) Fiscal Year 1984: ¥7,000,000 (Direct Cost: ¥7,000,000)
Keywords	animal models for human disease / transgenic mouse / DNA injection / HLA / renin / angiotensinogen / ミエリン塩基性タンパク貭
Research Abstract	Recent advances of biotechnology made it possible to produce trancegenic animals which are introduced by foreign DNAs. Transgenic mice are thougth to become animal models for human diseases, since their chromosomes are integrated by foreign DNAs, functions of that are closely related to the specific manifestation of the diseases. Transgenic mice which are produced are as follows. HLA 4, Renin-Angiotensinogen 37, growth hormon 6, oncogene 2, cytochrome P450 6, Interleukin-2 and its receptor 3, myelin basic protein 17, total 75 mice are produced. Expression of introduced genes are also examined. As far as renin and angiotensinogen genes are expressed in transgenic mice. However, others are now under investigation By means of producing transgenic mice, a new paradigm of experimental animals becomes open to investagation.