| Project/Area Number |
59480145
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Institute of Tropical Medicine, Nagasaki University |
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Principal Investigator |
ITAKURA Hideyo Department of Pathology, Institute of Tropical Medicine, Nagasaki University, 熱帯医学研究所, 教授 (00010512)
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| Co-Investigator(Kenkyū-buntansha) |
TORIYAMA Kan Department of Pathology, Institute of Tropical Medicine, Nagasaki University, 熱帯医学研究所, 助手 (00108359)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1986: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1985: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1984: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Kaposi's sarcoma / African endemic Kaposi's sarcoma / Classical Kaposi's sarcoma / Epidemic Kaposi's sarcoma / AIDS / Histogenesis / Geopathology / Burkitt's lymphoma / Kenya / AIDS |
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| Research Abstract |
Kaposi's sarcoma (KS) (Kaposi, 1872) is a soft tissue disease composed of angiogenetic tissue and spindle-shaped cells. The purpose of this study is to elucidate the latest findings of several points as follows: 1) Histogenesis: Studies employing immunohistochemistry and electron microscopy have suggested the origin of the tumor is pulripotential mesenchymal cells or endothelial cells of blood or lymphatic vessels. 2) Histopathology: In earlier stages, cutaneous edema and inflammatory cell infiltration are observed. Hemangiosarcoma-like patterns are observed frequently in the course of the disease. KS in advanced stages is composed of compact interlacing bundles of spindle cells. 3) Classifications: KS can be classified epidemiologically, clinically and histopathologically into three forms; African endemic form, classical form in Europe and North America and epidemic form of AIDS. 4) Epidemiology and geopathology: The relationship of KS to the natural environment, human ecology, socioeconomic conditions, genetic differences may be significant as a background for the occurence of KS. Our study revealed a geographical and ethnical coincidence of KS and Burkitt's lymphoma in Kenya, East Africa.
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