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Outbreak factors of histiocytic necrotizing lymphadenopathy

Research Project

Project/Area Number 59480147
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionDepartment of Pathology, School of Medicine, Fukuoka University

Principal Investigator

KIKUCHI Masahiro  Dept. Pathol., Sch. Med., Fukuoka Univ., Prof., 医学部, 教授 (80078774)

Co-Investigator(Kenkyū-buntansha) 三井 徹次  福岡大学, 医学部, 講師 (20099013)
IWASAKI Hiroshi  Dept. Pathol., Sch. Med., Fukuoka Univ., Assoc. Prof., 医学部, 助教授 (90101170)
EIMOTO Tadaaki  Dept. Pathol., Sch. Med., Fukuoka Univ., Assoc. Prof., 医学部, 助教授 (60140779)
MITSUI Tetsuji  Dept. Pathol., Sch. Med., Fukuoka Univ., Instructor
Project Period (FY) 1984 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1985: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1984: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsHistiocytic Necrotizing Lymphadenitis / T Cell / Viral Infection / <alpha> -interferon / オリゴアデニル酸合成酵素
Research Abstract

Aggregating cells in the affected foci in the lymph node of histiocytic necrotizing lymphadenitis, which affects usually Japanese and rarely reported in Caucasian, are mainly lymphocytes and and histiocytes. Almost of the lymphocytes consisted of T cells of both suppressor (CD <8^+> , Leu <15^+> ) and helper/inducer (CD 4) with the predominance of the former in the early stage and of the latter inthe later stage. After 60 days from onset the ratio of both subsets returned nearly the same as control ones. About 20% of the lymphocytes reacted with Ki67, a marker of cell proliferation and the proportion of the proliferating cells was slightly higher than that in the surrounding lymphoid tissue. No increase of natural killer cells and components and their receptors. The change of population of T cell subsets in process of time resembled those in protracted hypersensitivity reaction. As such reaction may sometimes be induced by viral infections, serum activity of 2'5' oligoadenylate synthetase, which relate to alpha interferon and elevates in acute of viral infection, was detected. The cases within 10 days after clinical onset demonstrated high activity of the synthetase. Appearance of tubuloreticular structures in lymphocytes, histiocytes and capillary endothelial cells, which may relate viral infection or activity of the cells, in affected foci on electron microscopy and the elevation of the activity of synthetase suggested strongly the relation to viral infection. To resolve viral nature of the lesion and the problem of high incidence of the lesion in Japanese gene analysis and investigation of HLA typing seemd to be the most useful methods.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Kikuchi,M.;Takeshita,M.;Tashiro,K.;Eimoto,T.;Okamura,S.: Virchow Arch.A.(Pathol.Anat.). 409. 299-311 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 竹下盛重,田代研児,三井徹次,菊池昌弘: 臨床血液 第28回総会抄録集. 370 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kikuchi,M.: International Colloquium on Lymphoid Malignancy.Immunology,Cytogenetics and Oncology.Kyoto,Sept.1987.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 竹下盛重,田代研児,岡村秀樹,三井徹次,内藤英明,菊池昌弘: 臨床血液 第27回総会抄録集. 317 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 菊池昌弘: "リンパ節炎ならびにリンパ節の反応性病変「現代病理学体系」18巻B 血液・造血器【II】" 中山書店, 280 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 菊池昌弘: "組織球性壊死性リンパ節炎・壊死性リンパ節炎「リンパ節の病理」" 文光堂, 236 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Takeshita,M., Tashiro,K., Okamura,H., Mitsui,T., Naitoh,H., Kikuchi,M.: "Immunohistologic study on histiocytic necrotizing lymphadenitis." The Japanese Journal of Clinical Hematology (Proceedings of 27th General Meeding). 317 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Takeshita,M., Tashiro,K., Mitsui,T., Kikuchi,M.: "2'5' oligoadenylate synthetase activity and histology of histiocytic necrotizing lymphadenitis." The Japanese Journal of Clinical Hematology (Proceedings of 28th General Meeting). 370 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kikuchi,M., Takeshita,M., Tashiro,K., Eimoto,T., Okamura,S.: "Immunohistological study of histiocytic necrotizing lymphadenitis." Virchow Arch. A. (Pathol. Anat.). 409. 299-311 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kikuchi,M.: "Histiocytic necrotizing lymphadenitis. Clinicopathologic and immunological study." International Colloquium on Lymphoid Malignancy. Immunology, Cytogenetics and Oncology. (Kyoto, September 1987).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kikuchi,M. (partial charge): Bunkodo. Histiocytic necrotizing lymphadenitis, Necrotizing lymphadenitis. In: Pathology of the Lymph Nodes, 38-40 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kikuchi,M. (partial charge): Nakayama-Shoten. Lymphadenitis and reactive lesions of lymph nodes. In: Modern Systemic Pathology Vol.18(B), (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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