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Biochemical and immunological studies on human hepatocellular carcinoma-Relation to integration of HBV-DNA.

Research Project

Project/Area Number 59480209
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionOkayama university

Principal Investigator

NAGASHIMA Hideo  Ist Dept. of Internal Med., Okayama University Medical School, 医学部, 教授 (70040144)

Co-Investigator(Kenkyū-buntansha) ARIMA Terukatsu  Ist Dept. of Internal Med., Okayama University Medical School, 医学部附属病院, 講師 (10116428)
Project Period (FY) 1984 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1985: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1984: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordscarbohydrate antigens / blood group-related antigens / hepatocellular carcinoma / HBV-DNA / lectins / レクチン / 組込み / サブゲノム
Research Abstract

Expression of carbohydrate antigens in human liver tissues and hepatocelular carcinomas was studied. L. Hepatocellular carcinoma was associated with the qualitative and quantitative changes of glycolipids. 2. From the study on the well characterized carbohydrate antigens, i.e., blood group-related antigens, the following conclusions were obtained. 1) Blood group antigens were expressed by biliary epithelial cells, but not by liver cells. 2) Biliary epithelial cells expressed a series of type 1 chain blood group antigens and difucosylated type 2chain antigens. 3) Expression of blood group antigens depended on the size of the bile ducts. This observation implied the

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 岡田良雄: 肝臓. 25. 1335 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 岡田良雄: Liver. 5. 226-235 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 岡田良雄: Analytical Ciochemistry. 147. 311-314 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 森近茂: Lancet. 2. 1431 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 羽田元: Liver. 6. 189-198 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 岡田良雄: Journal of Hepatology. 2. 430-440 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 岡田良雄: 肝臓. 27. 1188-1189 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 岡田良雄: Journal of National Cancer Institute. 78. 19-28 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 戸川三省: Gastroenterologia Japonica. 22. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 岡田良雄: Cancer.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 岡田良雄: Journal of Hepatology.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 岡田良雄: 肝臓.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 長島秀夫: "第13回犬山シンポジウム:肝癌細胞株、生検肝および血中のHBV-DNA検出とその臨床的意義" 中外医学社, 7 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 有馬暉勝: "肝胆膵:肝炎と肝癌の分子生物学的アプローチ" 国際医書出版, 15 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 有馬暉勝: "Medical Practice:肝硬変から肝癌発生・肝炎ウイルスに発癌性はあるのか" 文光堂, 5 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 有馬暉勝: "肝胆膵:肝胆膵疾患におけるモノクローナル抗体の応用" 国際医書出版, 13 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yoshio Okada: "Aberration of glycolipids in human hepatocellular carcinoma." Kanzou (in Japanese). 25. 1335 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yoshio Okada: "Human-hepatocellular carcinom is associated with quantitative and qualitative changes in glycolipids." Liver. 5. 226-235 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yoshio Okada: "Solid-phase radiolabeling of glycolipids with galactose-oxidase and sodium boro [ <^3H> ]hydride." Analytical Biochemistry. 147. 311-314 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Sigeru Morichika: "Hepatitis B virus DNA replication in peripheral blood mononuclear cells." Lancet. 2. 1431 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hajime Hada: "State of hepatitis B viral DNA in the liver of patients with hepatocellular carcinoma and chronic liver disease." Liver. 6. 189-198 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yoshio Okada: "Human hepatocellular carcinoma-associated changes of glycosphingolipids detected by two monoclonal antibodies FH2 and IB9." Journal of Hepatology. 2. 430-440 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yoshio Okada: "Expression of sialyl Le and sialyl Le carbohydrate antigens in hepatocellular carcinoma." Kanzou (in Japanese). 27. 1188-1189 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yoshio Okada: "Neoexpression of ABH and Lewis blood group antigens in human hepatocellular carcinomas." Journal of National Cancer Institute. 78. 19-28 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kazumi Togawa: "Subgenomic studies on hepatitis B virus DNA integrated into the genome of hepatocellular carcinoma tissue." Gastroenterologia Japonica. 22. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yoshio Okada: "Expression of ABH and Lewis blood group antigens in combined hepatocellular-cholangio carcinoma." Cancer.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yoshio Okada: "Blood group antigens in the intrahepatic biliary tree. 1. Distribution in normal liver." Journal of Hepatology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Yoshio Okada: "Sialylated Le -active glycoprotein expressed in chronic active hepatitis." Kanzou (in Japanese).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hideo Nagashima: Chugai Igakusha. HBV-DNA in a cell line, biopsy tissues and serum., 7 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Terukatsu Arima: Kokusai Isho Shuppan. Molecular approach for hepatitis and liver cancer, 15 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Terukatsu Arima: Bunkodo. Hepatocarcinogenesis from liver cirrhosis, 5 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Terukatsu Arima: Kokusai Isho shuppan. Monoclonal antibodies in the disease of liver, biliary tract and pancreas, 13 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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