| Project/Area Number |
59480209
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Okayama university |
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Principal Investigator |
NAGASHIMA Hideo Ist Dept. of Internal Med., Okayama University Medical School, 医学部, 教授 (70040144)
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| Co-Investigator(Kenkyū-buntansha) |
ARIMA Terukatsu Ist Dept. of Internal Med., Okayama University Medical School, 医学部附属病院, 講師 (10116428)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1985: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1984: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | carbohydrate antigens / blood group-related antigens / hepatocellular carcinoma / HBV-DNA / lectins / レクチン / 組込み / サブゲノム |
|---|
| Research Abstract |
Expression of carbohydrate antigens in human liver tissues and hepatocelular carcinomas was studied. L. Hepatocellular carcinoma was associated with the qualitative and quantitative changes of glycolipids. 2. From the study on the well characterized carbohydrate antigens, i.e., blood group-related antigens, the following conclusions were obtained. 1) Blood group antigens were expressed by biliary epithelial cells, but not by liver cells. 2) Biliary epithelial cells expressed a series of type 1 chain blood group antigens and difucosylated type 2chain antigens. 3) Expression of blood group antigens depended on the size of the bile ducts. This observation implied the
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