STUDY ON ETIOLOGY AND MORPHOGENESIS OF CONGENITAL HEART DISEASE.
| Project/Area Number |
59480234
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | MIYAZAKI MEDICAL COLLEGE |
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Principal Investigator |
HAYAKAWA KUNIO DEPARTMENT OF PEDIATRICS, MIYAZAKI MEDICAL COLLEGE, 医学部, 教授 (60041274)
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| Co-Investigator(Kenkyū-buntansha) |
SONODA TOHRU DEPARTMENT OF PEDIATRICS, MIYAZAKI MEDICAL COLLEGE, 医学部附属病院, 助手 (70187897)
OKISHIMA TAKAHIRO DEPARTMENT OF PEDIATRICS, MIYAZAKI MEDICAL COLLEGE, 医学部, 助手 (80136811)
SENNARI EIICHI DEPARTMENT OF PEDIATRICS, MIYAZAKI MEDICAL COLLEGE, 医学部附属病院, 講師 (60117439)
MATSUOKA YUJI DEPARTMENT OF PEDIATRICS, MIYAZAKI MEDICAL COLLEGE, 医学部附属病院, 講師 (10094103)
OHDO SHOZO DEPARTMENT OF PEDIATRICS, MIYAZAKI MEDICAL COLLEGE, 医学部, 助教授 (90041409)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1985: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1984: ¥3,400,000 (Direct Cost: ¥3,400,000)
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| Keywords | Congenital heart disease / Malformation / Genopathy / Chromosomal Aberration / 催奇形因子 |
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| Research Abstract |
GENETIC STUDIES OF CONGENITAL HEART DISEASES:
THE ETIOLOGIES OF 1,607 PATIENTS WITH CONGENITAL HEART DISEASES WHO VISITED OUR OUTPATIENT CLINIC DURING THE PERIOD FROM SEPTEMBER 1, 1981 TO JANUARY 31, 1987 were STUDIED. THESE PATIENTS INCLUDED 787 MALES (49.0%) AND 820 FEMALES (51.0%).
CLASSIFICATION BY THE CAUSES OF CONGENITAL HEART DISEASES REVEALED THAT A MAJORITY, 1,477 PATIETNS (91.9%), WERE IN THE GROUP WHOSE ETIOLOGY WAS IMPOSSIBLE TO CLARIFY. 97 PATIENTS (6.0%) EXHIBITED CHROMOSOMAL ABERRATION, 83.5% OF WHICH WAS COMPRISED OF DOWN SYNDROME. HEREDITARY DISEASES WERE RECOGNIZED IN 22 PATIENTS (1.4%), THEN THE PATIENTS WHO BELONGED TO RECOGNIZED SYNDROMES, AND FINALLY THE PATIENTS DUE TO ENVIRONMENTAL INSULTS.
EXPERIMENTAL STUDIES ON PATHOGENESIS OF CONGENITAL HEART DISEASES:
MORPHOGENESIS OF AN ABERRANT SUBCLAVIAN ARTERY WAS STUDIES BY ADMINISTERING 200mg OF BIS-DIAMINE TO PREGNENT RATS ON DAY 10 OF GESTATION.
WHEN THE AORTA DISPLAYED A LEFT AORTIC ARCH, THE BLOOD FLOW OF THE RIGHT 4TH AORTIC ARCH ARTERY WAS INTERRUPTED, AND A RIGHT DORSAL AORTA WAS SUPPLIED THROUGH THE RIGHT THIRD AORTIC ARCH ARTERY. CONSEQUENTLY, THE THIRD TO 7TH SEGMENT OF THE RIGHT DORSAL AORTA UNDERWENT REGRESSION. THE 8TH SEGMENT PERSISTED, FORMING THE PROXIMAL PART OF THE RIGHT SUBCLAVIAN ARTERY. THE DISTAL PART WAS FORMED FROM THE RIGHT 7TH INTERSEGMENTAL ARTERY, AND AROSE AS THE 4TH BRANCH FROM THE DESCENDING AORTA. WHENEVER THE AORTA WAS A RIGHT AORTA, AN AVERRANT LEFT SUBCLAVIAN ARTERY WAS A MIRROR IMAGE OF THE LEFT AORTA ARCH.
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Report
(1 results)
Research Products
(7 results)
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[Publications] Okishima,T.;Ohdo,S.;Hayakawa,K.: "Pediatric Cardiology.(Editors:Doyle,E.F.,Engle,M.A.,Gersony,W.M.,Rashking,W.J.,Talner,N.S.)" Spring-Verlag,New York, 4 (1986)
Description
「研究成果報告書概要(和文)」より
Related Report
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