Development of left ventricular assist system using pulsatile and nonpulsatile blood pumps
| Project/Area Number |
59480293
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Okayama university |
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Principal Investigator |
SENOO Yoshimasa Okayama University Medical School Assistant professor, 医学部, 助教授 (20033300)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Taiji Okayama University Medical School, Staff, 医学部付属病院, 助手 (10142332)
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| Project Period (FY) |
1984 – 1985
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| Project Status |
Completed (Fiscal Year 1985)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 1985: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1984: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Left heart bypass / pusher-plate pump / Left ventricular assist device / LV failure model / Regional myocardial blood flow |
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| Research Abstract |
Left heart bypass was performed in normal heart and also in failing heart, then the effects of left ventricular assist and total circulatory assist were evaluated by measuring the left ventricular contractility and the regional myocardial blood flow. By using 12 goats weighing 44.5Kg, left heart bypass was performed in normal heart, then in failing heart which was produced by injecting NaOH into the myocardium. Blood was drained from the left atrium and was returned to the descending thoracic aorta. The pusher-plate pump was driven in variable rate mode. The stroke volume of the blood pump was 60ml and it was driven by compressed air. Regional myocardial blood flow was measured by using hydrogen gas clearance method. In order to produce left heart failure model, NaOH was injected into the left ventricular myocardium 0.079(]SY.+-。[)0.014ml/Kg. The weight ratio of the myocardial necrosis to the left ventricular free wall was 22.7 (]SY.+-。[) 7.74%. After creating a left ventricular failure model, cardiac output, arterial pressure, LV max dp/dt, and TTI decreased significantly.
Following the left heart bypass was performed in normal heart, cardiac output, LV max.dp/dt and RMBF decreased significantly. The left heart bypass in the failing heart showed significant decrease in RMBF,significant increase in cardiac output and arterial pressure, and significant decrease in A-VDO2. Left ventricular max. dp/dt and TTI did not show significant decrease after the left heart bypass. These data suggested that total body circulation was maintained by using left heart bypass in the failing heart, but left ventricular decompression was not obtained.
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Report
(1 results)
Research Products
(4 results)
