| Project/Area Number |
59480304
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
NISHIMOTO Akira OKAYAMA UNIVERSITY MEDICAL SCHOOL PROFESSOR, 医学部, 教授 (50032850)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMI Nobuhiko OKAYAMA UNIVERSITY HOSPITAL SENIOR RESIDENT, 医学部・附属病院, 医員
TAMIYA Takashi OKAYAMA UNIVERSITY HOSPITAL SENIOR RESIDENT, 医学部・附属病院, 医員
MORIYAMA Eiji OKAYAMA UNIVERSITY HOSPITAL SENIOR RESIDENT, 医学部・附属病院, 医員
MATSUMOTO Kengo OKAYAMA UNIVERSITY HOSPITAL ASSISTANT, 医学部・附属病院, 助手 (10190521)
FURUTA Tomohisa OKAYAMA UNIVERSITY MEDICAL SCHOOL, 医学部, 助手 (30181457)
守山 英二 岡山大学, 医学部附属病院, 医員
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1986: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1985: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1984: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | HYPERTHERMIA / DIFFERENTIAL HYPOTHERMIA / MICROWAVE ANTENNA / MALIGNANT GLIOMA / LOCAL CEREBRAL BLOOD FLOW / 局所脳血流量 / 血流動態 |
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| Research Abstract |
For the purpose of the clinical application of the differential hypothermia for human malignant brain tumors, we have studied the area and the depth that were affected by the external microwave irradiation.
In order to heat more exact area at more exact temperature, next in vivo experiments were performed by using the interstitial microwave irradiation antenna. Under the generalized hypothermia (30ﾟC), a microwave antenna heated the area within 2 cm radius from the antenna and 3cm in depth from the brain surface at the degree of over 37ﾟC.This result indicated the therapeutic effect.
But it is one of the problems with this system that because of the overheating (more than 50ﾟC) of the antenna surface, coagulation, necrosis and bleeding were observed in the tissues adjacent to the antenna. In order to prevent the overheating, a antenna cooling system for interstitial microwave therapy was developed, which was constructed of a silicone tube 5.0 mm in outer diameter. Cooling provided by con
… More
stant water perfusion allowed more uniform and accurate heating in the tissue temperatures the range of 42 to 44ﾟC within 1 cm radius. And the safety of this system was ensured by the histological examination.
Moreover a square array (1.6cm on a side) of four antennae was inserted into the brain with the coupled cooling system. In this four-antennae experiments, thermal field was dramatically flattened with minimal reduction in size ; however, the area maintained at a therapeutic temperature range (42-45ﾟC) was significantly enlarged by the cooling system.
Under differential hypothermia, the lical cerebral blood flow (1-CBF) before and after the heating of the normal monkey brain was measured. Before heating, the 1-CBF of the white matter was 18.7<plus-minus>9.8ml/100g brain/min, after heating (30ﾟC), that was increased about two hold compared with before heating. This selective increase of CBF was favorable for the chemotherap
In future, we attend to develop more effective antenna and the antenna guiding system, to investigate the change of the heated normal brain tissue from the pathological point of view and to examine the limiting point of heating the brain tissue. Less
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