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Studies on Vascularized Allogeneic Joint Graft

Research Project

Project/Area Number 59480310
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

MINAMI Akio  Hokkaido University Hospital Lecturer, 医学部, 助手 (20133738)

Co-Investigator(Kenkyū-buntansha) NATORI Takashi  Hokkaido University, School of Medicine Instractor, 医学部, 助手 (00001892)
OGINO Toshihiko  Hokkaido University Hospital Lecturer, 医学部附属病院, 講師 (60109436)
USUI Masamichi  Sapporo Medical College Associate Prof., 助教授 (90002328)
TAKEICHI Noritoshi  Hokkaido University, School of Medicine Associate Prof., 医学部, 助教授 (40002133)
Project Period (FY) 1984 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1986: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1985: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1984: ¥3,200,000 (Direct Cost: ¥3,200,000)
KeywordsVascularized Joint Graft / Allogeneic Graft / Autologous Graft / Rat Major Histocompatibility Antigen / マイクロサージャリー
Research Abstract

The experimental studies using rats were designed to investigate; (1)the effect of vascularity on autologous and allogeneic joint transplantations, (2)the influence of major histocompatibility antigen on survival and functioning of grafted joints.
Knee joints from 5 strains of the inbred rat were used in our study. The rats were classified into 2 groups. I:Vascularized autologous joint transplantation (from WKA to WKA rats) II:Vascularized allogeneic joint transplantation. Group II was further classified into 4 subgroups according to the difference of haplotypes (subregions) of rat major histocompatibility (RT1) antigens between the donor and recipient rat:1)RT1-A.B.D. barrier (from WKA to LEJ rats), 2)RT1-B.D. barrier (from TO to LEJ rats), 3)RT1-A. barrier (from BUF to LEJ rats), and 4)non-RT1 barrier (from WKA to W rats). Roentogenograms and 99m-Tc scintigrams were taken every 1 week after joint transplantation to investigate the time of bone healing and revascularization of transplanted joints. Histological studies were also performed.
Roentgenograms revealed that the bone healing began at 2.6 weeks post-operatively in Group I and Group II-4). The periosteal reaction of the transplanted joints wan not observed until 10 weeks post-operatively in Group II except in subgroup 4).
Scintigrams showed the immediate vascularity of transplanted joint in Group I and Group II-4). The vascularization of transplanted joint was observed until 2 weeks post-operatively in Group II-1), 2), and 3to 4 weeks in Group II-3). However, in Group II except in subgroup 4) bone, articular cartilage and surrounding muscle tissue became to be necrosis.
These studies suggest that the success of the vascularized allogeneic joint transplantation is dependent on the vascularity and low antigenicity of transplanted joint.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Minami,A.;Usui,M.;Katoh,H.;Ishii,S.: The Journal of Hand Surgery(British volume).9. 239-244 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Natori,T.;Fujimoto,Y.;Ikeda,H.;Ishikawa,N.;Ishikura,H.;Matsuno,Y.;Tsuchimoto,S.;Mizuno,K.;Niiyama,T.;Cramer,D.;Aizawa,M.: Immunogenetics. 22. 511-516 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Tsuchimoto,S.;Mizuno,K.;Matsuno,Y.;Niiyama,T.;Cramer,D.;Natori,T.;Aizawa,M.: Transplantation. 40. 218-220 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 佐久間隆,荻野利彦,三浪明男,福田公孝,伊藤和夫: 日本手の外科学会雑誌. 2. 25-29 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Minami,A.;Usui,M.;Ogino,T.;Minami,M.: Microsurgery. 7. 38-45 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 佐久間隆,荻野利彦,三浪明男,福田公孝,野島孝之: 日本手の外科学会雑誌. 3. 373-376 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 三浪明男,荻野利彦,佐久間隆 著,真角昭吾編集: "骨・軟骨移植の基礎と臨床" 南光堂, 5 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 名取孝 著,山村雄一編集: "Genetic Background in Immunoregulation and Induction of Immune Disorders" 同文書院, 18 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Minami,A.; Usui,M.; Katoh,H.; Ishii,S.: "Thumb reconstruction by free sensory flaps from foot usinf microsurgical techniques." The Journal of Hand Surgery. 9-B. 239-244 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Natori,T.; Fujimoto,Y.; Ikeda,H.; Ishikawa,N.; Ishikura,H.; Matsuno,Y.; Tsuchimoto,S.; Mizuno,K.; Niiyama,T.; Cramer,D.; Aizawa,M.: "The RT1.B/D-region products defined by rat monoclonal alloantibodies." Immunogenetics. 22. 511-516 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Sakuma,T.; Ogino,T.; Minami,A.; Fukuda,K.; Itoh,K.: "Experimental studies on vascularized allogeneic joint graft. I: Effect of vascularization and histocompatibility antigen on survival of grafted joint." Journal of Japanese Society for Surgery of the Hand. 2. 25-29 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Minami,A.; Usui,M.; Ogino,T.; Minami,M.: "Simultaneous reconstruction of bone and skin defects by free fibular graft with a skin." Microsurgery. 7. 38-45 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Sakuma,T.; Ogino,T.; Minami,A.; Fukuda,K.; Nojima,T.: "Experimental studies on vascularied allogeneic joint graft. II: Circulation and histological findings of grafted joints." Journal of Japanese Society for Surgery of the Hand. 3. 373-376 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Minami,A.; Ogino,T.; Sakuma,T.: Nankoudo, Tokyo. Allogeneic joint graft and transplantation immunity., 8-12 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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