| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1984: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Research Abstract |
The encephale isole cat preparations were carefully maintained in a sound condition with spontaneously alternating sleep-waking phases. By recording the intracellular potentials of motor cortical neurones, we investigated the temporal and spatial patterns of intracortical spread of activities produced by stimulating three input pathways to the cortex that were relevant to generation of various electrocortical rhythmic waves. The responses to the direct cortical surface stimulation started in the most superficial layers with short-latency monosynaptic excitation, and spread horizontally and vertically towards the deep layers, in which long-latency polysynaptic excitation, inhibition, disfacilitation, and disinhibition occurred. These responses were transmitted across laminae in a cascade manner from superficial to deep layers, and were proved to be identical with those induced during the initial phasic phase of electrocortical arousal with the well-known low voltage fast pattern. The responses to the cerebral peduncle stimulation were observed in middle and deep layer cells as excitation, inhibition, or the both combined with the latencies shorter in deep than in middle layer cells. The responses to the ventrolateral thalamic stimulation consisted of excitation, inhibition,or the both, of the latencies shortest in the middle layer with the tendency of prolongation towards both the surface and the depths. Comparison of the responses in respective neurones to the three input stimulations has revealed that the cortical surface and thalamic inputs activate the common neuronal assemblies with the identical response repertoire in contrast to the peduncle input for which the responses are somewhat different from those to the other two inputs. Preliminary examinations were also made on the configuration of electrocortical spindle waves induced spontaneously and by the cortical surface or thalamic stimulation.
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