| Project/Area Number |
59570175
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
寄生虫学(含医用動物学）
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
MIURA SACHIO 慶応義塾大学, 医学部, 助手 (30051858)
|
|---|
| Project Period (FY) |
1984 – 1988
|
| Project Status |
Completed (Fiscal Year 1988)
|
| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1985: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1984: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | Nude rat (rnu / rnu) / Trypanosoma cruzi / Macrophage / Lysosome |
|---|
| Research Abstract |
5. The amount of oxygen radicals was measured and compared between macrophages from the nude rats and the littermates. The oxygen radicals were determined utilizing a luminol-mediated chemiluminescence. The amount was found approximately 10 times more in macrophages of the littermates, when stimulated with FMLP or viable trypomastigotes of T. cruzi. The velocity of production of oxygen radicals was also faster in the macrophages from the littermates. The similar data have been also obtained with Leishmania.
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