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Studies on Clostridium difficile enterotoxin

Research Project

Project/Area Number 59570185
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 細菌学
Research InstitutionGifu University School of Medicine

Principal Investigator

UENO Kazue  Gifu University School of Medicine, 医学部, 教授 (20021363)

Co-Investigator(Kenkyū-buntansha) MUTOH Yoshinori  Gifu University School of Medicine, 医学部, 助手 (80190859)
KATOH Naoki  Gifu University School of Medicine, 医学部, 助手 (00108078)
WATANABE Kunitomo  Gifu University School of Medicine, 医学部, 講師 (70108067)
Project Period (FY) 1984 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1984: ¥800,000 (Direct Cost: ¥800,000)
KeywordsC.difficile / Enterotoxin / Antibiotic-associated diarrhea / 小腸粘膜の変化;病院内感染 / C.perfringens typeA
Research Abstract

Measurement of C.difficile and their toxin in fecal samples of antibiotic associated diarrhea;
The results showed that the detection of the C.difficile and C.difficile enterotoxin were extremely correlated. 4 cases out of 11 were positive for both C.difficile and their enterotoxin, and 7 cases were found to be negative for both C.difficile and their enterotoxin. Measurement of C.difficile enterotoxin showed that fecal samples from healthy subjects contained 0 - 255 ng/ml toxin, on the other hand, that of the patients with antibiotic-associated diarrhea ranged between 1500 - 6500 ng/ml.
We suggested that C.difficile enterotoxin may be one of the main causative toxin for the antibiotic-associated diarrhea or pseudomembranous colitis. Changes of intestinal microflora on the antibiotic-associated diarrhea due to C.difficile;
The results showed that Enterococcus faecalis in intestinal contents may be important for the over growth of C.difficile in the intestine who had antibiotics.

Report

(1 results)
  • 1986 Final Research Report Summary

Research Products

(4 results)

All Other

All Publications (4 results)

  • [Publications] 神野英毅: 医学のあゆみ. 136. 973-974 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hideki Kohno: Acta Sch.Med.Univ.Gifu. 35. 73-87 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hideki Kohno: "Studies on the clinical significance of Clostridium difficile enterotoxin" Igaku no ayumi. 136. 973-974 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hideki Kohno: "Studies on Clostridium difficile enterotoxin Its partial purification and immunoassay in fecal samples" Acta Sch. Med.Univ. Gifu. 35. 73-87 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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