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Regulatory system of epidermal adenylate cyclase-cyclic AMP system

Research Project

Project/Area Number 59570413
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionHokkaido University (1986)
Asahikawa Medical College (1984-1985)

Principal Investigator

OHKAWARA Akira  Hokkaido University School of Medicine, Professor, 医学部, 教授 (50000964)

Project Period (FY) 1984 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1984: ¥700,000 (Direct Cost: ¥700,000)
Keywordscyclic AMP / adenylate cyclase / glucocorticoid / colchicine / retinoid / 尋常性乾癬
Research Abstract

Glucocorticoid ( hydrocortisone ) augmented the beta-adrenergic adenylate cyclase response of epidermis. The effect was observed by other glucocorticoids ( prednisolone and dexamethasone ) but not androgens or estrogens. Potent glucocorticoids revealed the beta-adrenergic augmentation effect at lower concentrations. Protein synthesis inhibitors ( actinomycin D, cycloheximide and puromycin ) inhibited the beta-adrenergic augmentation effect by the glucocorticoid. These compounds, however, revealed the beta-adrenergic augmentation effect when added singly to the incubation medium at a restricted range of concentrations. Besides glucocorticoids, microtubules disruptive agent ( colchicine ) and retinoids ( retinoic acid, RO 10-1670, E-5166 ) revealed the beta-adrenergic augmentation effect. The effect by these 3 types of chemicals were apparently independent each other. Psoriatic involved epidermis has been characterized by a defective beta-adrenergic adenylate cyclase response of epidermis. Although many antipsoriatic agents, which include glucocorticoids,colchicine and retinoids, revealed the beta-adrenergic augmentation effect, the significance of these findings in terms of the regulatory system of keratinocyte proliferation remains unknown at present.

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Akira Ohkawara: Archives of Dermatological Research. 277. 88-92 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hajime Iizuka: Archives of Dermatological Research. 277. 466-472 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hajime Iizuka: The Journal of Investigative Dermatology. 85. 324-327 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hajime Iizuka: Acta Dermato-Veneologica. 65. 459-464 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hajime Iizuka: Clinical and Experimental Dermatology. 11. 238-245 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Akira Ohkawara: "Glucocorticoid-Induced Alteration of Beta-Adrenergic Adenylate Cyclase Response of Epidermis" Archives of Dermatological Research. 277. 88-92 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hajime Iizuka: "Modulation of Pig Epidermal Adenylate-Cyclase Responses by Protein-Synthesis Inhibitors: Its Relation to Glucocorticoid and Colchicine Effects" Archives of Dermatological Research. 277. 466-472 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hajime Iizuka: "Effects of Retinoids on the Cyclic AMP System of Pig Skin Epidermis" The Journal of Investigative Dermatology. 85. 324-327 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hajime Iizuka: "A New Synthetic Retinoid, E-5166, Augments Epidermal Beta-adrenergic Adenylate Cyclase Response" Acta Dermato-Veneologica. 65. 459-464 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hajime Iizuka: "Antipsoriatic and antimetabolic agents as stimulators of the beta-adrenergic adenylate cyclase response of epidermis" Clinical and Experimental Dermatology. 11. 238-245 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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