| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1984: ¥800,000 (Direct Cost: ¥800,000)
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| Research Abstract |
Ultrasonic tissue characterization study can play important role in establishing useful diagnostic criteria for various malignant diseases, therefore these studies were carried out in the viewpoints of correlations between echo-signs and tissue characteristics of various malignant and benign neoplastic diseases such as breast cancer,benign breast tumors,malignant lymphoma and leukemic infiltration and so on.
Various echographic characteristics and their ultrasonic tissue characterization were analysed in various types of breast tumors such as medullary carcinoma, papillary carcinoma,scirrhous carcinoma,malignant lymphoma,lymphatic infiltration, benign cyst,fibroadenoma,cystosarcoma phylloides,gynecomastia and nodular fibrosis with fat necrosis. Collagen fiber content within breast tumor tissue played important role in casting acoustic shadow behind the tumor (acoustic middle shadow sign - AMSS),especially in the case of scirrhous carcinoma, whereas rich epitherial cell component could produce the accentuation of ultrasonic energy; tadpole-tail sign (TP) and lateral shadow sign (LS) in the case of medullary carcinoma.
This typical phenomenon could also be observed in the cases of fibroadenoma. Two malignant breast diseases; the infiltration of lymphatic leukemia and Hodgkin's diseases,both rich in tumor cell components and less in collagen fiber contents, produced the the tadpole-tail sign and the lateral shadow sign.
The echographic characteristics and ultrasonic tissue characterization of malignant lymphoma were also carried out, and the echo-characteristics were hypoechoic in nature in all lymphatic involved lesions such as in the liver.the spleen, and peripancreatic,para-aortic,hepatic and splenic hilar/lymph nodes, andit was concluded that the rich cellularity in the homogeneous nature when compared with the surrounding structure,can produce hypoechoic lesion in routine clinical echograms.
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