| Project/Area Number |
59570534
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | UNIVERSITY OF TOKYO |
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Principal Investigator |
KURUMADO KATSUMARO FACULUTY OF MEDICINE, LECTURER, 医学部, 講師 (50101118)
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| Co-Investigator(Kenkyū-buntansha) |
OOHARA TAKESHI FACULTY OF MEDICINE, PROFESSOR, 医学部(分), 教授 (20010217)
IHARA OSAMU FACULTY OF MEDICUNE, ASSOCIATE PROFESSOR, 医学部(分), 助教授 (60010550)
YAHANO TAKEMITSU SOKA CITY HOSPITAL, MEMBER OF DEPARTMENY OF SURGERY, 医師 (70126192)
KURAMOT SHU FACULTY OF MEDICINE, ASSISTANT, 医学部(分), 助手 (10153371)
JOJIMA YOSHIAKI FACULTY OF MEDICINE, ASSISTANT, 医学部(分), 助手 (40010508)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1984: ¥600,000 (Direct Cost: ¥600,000)
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| Keywords | Density of mucosal nerves / Transmission electron microscopy / Mice / Chronological change / Intestinal metaplasia of human stomach / Tumorous lesions of human colonic mucosa / 粘膜上皮の分化とその維持 |
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| Research Abstract |
CHRONOLOGICAL CHANGES OF GASTRIC MUCOSAL NERVES OF MICE AND DENSITY OF MUCOSAL NERVES OF OF HUMAN GASTRIC MUCOSA WITH INTESTINAL METAPLASIA WERE STUDIED BY TRANSMISSION ELECTRON MICROSCOPY. NO REMARKABLE CHANGE OF GASTRIC MUCOSAL NERVES OF OLD MICE WAS OBSERVED REGARDLESS OF MILD MUCOSAL ATROPHY WITHOUT INTESTINAL METAPLASIA. REMARKABLE NERVE DEPLETION WAS FOUND IN HUMAN ATROPHIC GASTRIC MUCOSA WITH INTESTINAL METAPLASIA. FROM THESE OBSERVATIONS, IT WAS SHOWN THAT MUCOSAL NERVES MIGHT PARTICIPATE IN DIFFERENTIATION AND ITS MAINTENANCE OF GASTRIC MUCOSAL EPITHELIUM.
NO DEFINITE PARTICIPATION OF MUCOSAL NERVES IN DIFFERENTIATION AND ITS MAINTENANCE OF COLONIC MUCOSAL EPITHELIUM WAS DEDUCED BY COMPARING MUCOSAL NERVE DENSITY OF HYPERPLSATIC POLYP, ADENOMATOUS POLYP AND COLONIC CANCER.
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