| Project/Area Number |
59570598
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | 2nd Depart. of Surg., Okayama University Medical School. |
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Principal Investigator |
SHIMIZU Noguyoshi 2nd Departmen tof Surgery, Okayama University, 医学部附属病院 第二外科, 助手 (90108150)
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| Co-Investigator(Kenkyū-buntansha) |
長澤 弘明 岡山大学, 医学部附属病院・第二外科, 医員
栗田 啓 岡山大学, 医学部附属病院・第二外科, 医員
TERAMOTO Shigeru 2nd Depart. of Surg.,Okayama University Medical School, 医学部・第二外科, 教授 (60033049)
NAGASAWA Hiroaki 2nd Depart, of Surg.,Okayama University Medical School
KURITA Akira 2nd Depart. of Surg.,Okayama University Medical School
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| Project Period (FY) |
1984 – 1985
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| Project Status |
Completed (Fiscal Year 1985)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1985: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1984: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | postoperative pulmonary function / perfusion scintigraphy / excercise test |
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| Research Abstract |
We have been performed respiratory function test and pulmonary perfusion scintigraphy in patients with lung cancer in order to achieve pulmonary resection safely. Using these tests, postoperative respiratory function after pulmonary resection was predicted precisely. In addition to these tests, maximum oxygen consumption ( Vo_2 max ) was measured during maximal exercise test in preoperative patients in order to know pulmonary circulation reserve and then, its correlation to the respiratory function test studied.
Till the end of 1985,147 patients with lung cancer were evaluated. In these patients, after respiratory function test was done, maximal oxygen consumption was calculated using expiratory gas analyzer. When DLCO was under 20 ml/min/mmHg and Vo_2 max was under, 1,100 ml/min, it was found that cardiopulmonary function reserve decreased significantly and the incidence of complications increased.
We are now studying anaerobic metabolism during the exercise test. Especially, the relationship between the rapid increase in blood lactate and the quantity of exercise is now under the investigation. These studies are extremely important to estimate cardiopulmonary reserve because the number of high risk aged patients, who undergo pulmonary resection, are increasing from now on.
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