| Project/Area Number |
59570607
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Institute of Clinical Medicine, Tsukuba University, |
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Principal Investigator |
NOSE Tadao Institute of Clinical Medicine,Univ.Tsukuba.,Associate Professor., 臨床医学系, 助教授 (10009699)
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| Co-Investigator(Kenkyū-buntansha) |
TOMONO Yuuji Institute of Clinical Medicine,Univ.Tsukuba.,Assistant Professor., 臨床医学系, 講師 (70110335)
YOSHII Yoshihiko Institute of Clinical Medicine,Univ.Tsukuba.,Assistant Professor., 臨床医学系, 講師 (50110507)
ENOMOTO Takao Institute of Clinical Medicine,Univ.Tsukuba.,Assistant Professor., 臨床医学系, 講師 (10134230)
NAKAGAWA Kunio Institute of Clinical Medicine,Univ.Tsukuba.,Assistant Professor., 臨床医学系, 講師 (40092077)
HOMMA Kazuhiro Mechanical Engneering Laboratory, MITI., 機械技術研究所・バイオメカニクス課, 研究員 (80357970)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1984: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Nuclear Magnetic Resonancce Image / Expelimental Brain Disease / Gd-DTPA / Intracerebral Hemorrhage / 脳腫瘍 |
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| Research Abstract |
The MRI system used in this study is CPX 20tb (Registive magnet,0.477T,Bruker) We analised MR images of various experimental animal models using the pulse sequences of inversion recovery as Tl weighted image (1500/250,1500/500,1500/750) and CPMG as proton density and T2 weighted images (1000/-32,1000/-64,1000/-96).
1) Intracerebral hematoma; The hematoma can be detected within the first 6 hours after hematoma formation, it is not visible on MR image but thereafter again hematoma become visible on MR image.
2) Experimental brain tumor ( Glioma 9L ); The tumor is expressed as prolonged area of Tl and T2 relaxiation times on the MR image but periforcal edimatous zone is also expressed in the same way, making differentiation between them a difficult one. But the enhancing technique using Gd-DTPA ,the edematous area was easily differentiated from the tumor itself. On the bases of the fact that clearance of Gd-DTPA is delayed in the former area. This fact was further substantiated by the experment using experimental autoradiogram using Gd-14C-DTPA.
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