| Project/Area Number |
59570631
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Gunma University School of Medicine |
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Principal Investigator |
UDAGAWA Eiichi Dept. Orthop. Gunma University School of Medicine, 医学部, 教授 (70009976)
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| Co-Investigator(Kenkyū-buntansha) |
CHIGIRA Masaki Dept. Orthop. Gunma University School of Medicine, 医学部, 助手 (70143196)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1984: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Biomaterials / Ceramics / Antigenicity / Immunogenitics / Oxidation-reduction reaction / Loosening / Inflammation / 吸着 |
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| Research Abstract |
Significant footpad swelling was observed in mice immunized with tricalcium phosphate ceramic at 2 and 4 weeks after immunization. Antigenic specificity was demonstrated in cross-over design. Time course of the reaction suggest that delayed-type hypersensitivity played an important role. On the other hand, mice were died after administration of apatite-wollastonite glass ceramic. The death was induced by the ceramic powder itself, and was not induced by the supernatant of the powder. Significant footpad swelling showed the presence of delayed-type hypersensitivity against apatite-wallostonite. The adsorption behavior of cytochrome c on silica obeys the Langumuir adsorption irotherm. Furthermore, silica induced electron transfer of cytochrome c.
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