| Project/Area Number |
59570726
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
KATO Toshi Kurume University,Professor, 医学部, 教授 (60080876)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Takashi Kurume University,Instructor, 医学部, 講師 (70140712)
YAKUSHIJI Michiaki Kurume University,Associate Professor, 医学部, 助教授 (70080877)
|
|---|
| Project Period (FY) |
1984 – 1986
|
| Project Status |
Completed (Fiscal Year 1986)
|
| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1984: ¥700,000 (Direct Cost: ¥700,000)
|
|---|
| Keywords | Experimental ovarian tumor / DMBA / Adenocarcinoma / Intrasplenic transplantation / Granulosa cell tumor / Teratoma / LT / Sv / Fetectomy |
|---|
| Research Abstract |
1. OVARIAN TUMORS INDUCED BY DIRECT APPLICATION OF DMBA TO THE OVARY
Direct application of DMBA to the ovary successfuly induces rat ovarian neoplasms. most of them are concomitant adenocarcinoma consisted of serous and endometrioid (occasionally with squamous metaplasia) type components. Biologic behavior of them are closely similar to human ovarian cancer, and the surface epithelial proliferations were observed in the early experimental period. The second is fibrosarcoma,although histogenic process remains to prove. The final type is also adenocarcinoma showing completely acinar structures. They develop in the hilar region without surface cell proliferation, suggesting the tumors are not the drivation of the surface cells. The incidence of the latter two type tumors are low(about 2%).
2. INTRASPLENIC TRANSPLANTATION OF GONADAL TISSUES
Granulosa cell tumors develop from intrasplenic ovarian tissue, although most of them are benign, as reported. When DMBA-treated ovary was implanted, adenocarcinoma or malignant granulosa cell tumor with extrasplenic development and cellular pleomorphism was observed. Of interests, tumors from intrasplenic testis have Sertoli cell components and granulosa cell elements.
3. INDUCTION OF TERATOMA
Teratoma in ddy mice received fetectopmy was compared with spontaneously occurred teratoma in LT mice. The histology similar to that of LT mouse teratoma, although extraembryonic tissues were completely lack in the tumor in ddy mice.
|
