| Project/Area Number |
59570801
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Aichigakuin University |
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Principal Investigator |
SATOH Toyohiko Aichigakuin University Dental School, Professor, 歯学部, 教授 (80064830)
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| Co-Investigator(Kenkyū-buntansha) |
大島 利洋 愛知学院大学, 歯学部, 助手
横田 たつ子 愛知学院大学, 歯学部, 助手 (70192416)
YAMADA Shigeru Aichigakuin University Dental School, Instructor, 歯学部, 助手 (90175662)
EGUCHI Kunihiro Aichigakuin University Dental School, Instructor, 歯学部, 助手 (30113062)
SHINBA Toshikazu Aichigakuin University Dental School, Instructor
WATABE Kazushige Aichigakuin University Dental School, Lecturer
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1986: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1985: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1984: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Tooth pulp / Tooth pain / Trigeminal spinal nucleus / Single-neuron activity / Sleep / Raphe nucleus / Serotonin-containing neuron |
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| Research Abstract |
[1984] (1) Single-neuron activities and slow mass potentials evoked by stimulating the rat tooth pulp were recorded. The ratio of the stimulus intensity to the response magnitude was usually greater in the single-neuron activity than in the amplitude of slow mass potentials. The stimulus - response relation in neurons with short latency could be described rather well by power function, while neurons with long latency could be approximated more closely by linear function. (2) The raphe neurons projecting to the trigeminal spinal nucleus of the rat could be divided into two groups: Neurons inside the raphe had a long antidromic latency which was gradually increased following repetitive high frequency stimulation. Neurons around the raphe had a short and stable antidromic latency. (3) The dopamine-containing neurons of the rat which are located in the ventral tegmental area and projceting to the accumbens nucleus showed also a gradual latency prolongation upon repetitive high frequency activation.
[1985] The dorsal raphe neurons of the cat showed a gradual latency prolongation upon repetitive high frequency activation. The main mechanism of the latency prolongation was suggested to be mainly in the axonal membrane stimulated and partly in the synaptic inputs to the soma.
[1986] Cats were chronically prepared to investigate the variability during natural sleep-waking cycle of the single-neuron responses evoked in the trigeminal nucleus by electrical stimulation of the tooth pulp. The spike number evoked by a low stimulus intensity was employed as the index representing the influence from the sleep regulating system. The ratio of the response at high intensity stimulation to the response at low intensity stimulation was used as the index representing the influence from the pain modulating system. It was found that in about one half of the neurons examined these two indexes tended to change during sleep in a reciprocal manner.
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