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Studies on the identification of ABH antigens between red cell and saliva

Research Project

Project/Area Number 59870023
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionTohoku University

Principal Investigator

SAGISAKA Kaoru  東北大学, 医, 教授 (70006740)

Project Period (FY) 1984 – 1985
Project Status Completed (Fiscal Year 1985)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1985: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1984: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsABH blood group / Red cell / Saliva
Research Abstract

To distinguish ABH antigens between red cell and saliva, we attempted to immunize various animals with red cell and saliva. Absorption of rabbit antisera to O . A red cell, O. B saliva with appropriate red cell and saliva resulted in specific antibody to the immunogen (anti-Hr,-Ar,-Hs and Bs). Rabbit was divided into two groups ( <A^+> and <A^-> ) according to its secreting ability of A antigen in saliva. Specific anti-Ar was produced in only <A^+> rabbit. It meant that A+ rabbit had A antigen shared with human A saliva. On the other hand, anti-As could be prepared in rabbit but not in guinea pig. The agglutinin titers of anti-Hr,-Hs and Bs) were relatively high, but the others were low. The titers of the antisera to saliva antigen were tested with latex coated with saliva of the corresponding group. However, anti-Br was raised in neither rabbit, guinea pig nor chicken. In this experiment, antiHr,Hs,Bs sera were easily prepared but antiAr and As were produced after immunization of many trials of immunization. At any rate, it was considered that these antisera specific for red cell or saliva ABH antigens were useful for forensic practice in criminal cases.

Report

(1 results)
  • 1985 Final Research Report Summary
  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] 日本法医学雑誌. 39巻-6号. (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1985 Final Research Report Summary
  • [Publications] Oral presentation at 69th annual meeting of Medico-Legal Society of Japan held at Morioka on 22-24 May, 1985. (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1985 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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