| Project/Area Number |
59870033
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
|
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| Research Institution | Showa University |
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Principal Investigator |
HARUMI Kenichi (1985) 昭和大学, 医, 教授 (00102335)
春見 健一 昭和大学, 医学部, 教授
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|---|
| Project Period (FY) |
1984 – 1985
|
| Project Status |
Completed (Fiscal Year 1985)
|
| Budget Amount *help |
¥7,200,000 (Direct Cost: ¥7,200,000)
Fiscal Year 1985: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1984: ¥5,500,000 (Direct Cost: ¥5,500,000)
|
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| Keywords | Cardiac excitability / Train pulse / Dip phenomenon / Ventricular fibrillation threshold / 抗不整脈剤 |
|---|
| Research Abstract |
The classification of antiarrhythmic drugs was proposed from the standpoint of ventricular excitability. The following parameters for this purpose were obtained by the anodal stimulation and anodal train pulses of 50 Hrz; relative refractory period RRP (threshold was 1mA),endodiastolic threshold (EDT), supernormal period (CSP), dip phenomenon(DP) and ventricular fibrillation threshold (VFI) which was determined by the 50 Hrz train pulses less than the current intensity of 1 mA and the duration of 1.8 sec.The antiarrhythmic drugs may be classified into 5 groups by these parameter in the table. Lidocaine was included in E grorp, Procaineamid in B for example.
RRP(1mA) EDT DP ＆ SP VFT
(prolonged) (increased) (disappear) (increased)
A + - - -
B + - - +
C + + - +
D + - + +
E + + + +
|
