| Project/Area Number |
59870037
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Nihon University |
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Principal Investigator |
KITAGAWA Teruo Professor of Peidatrics, Nihon Univ. School of Medicine, 医学部, 教授 (50058765)
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| Co-Investigator(Kenkyū-buntansha) |
片山 純男 (株)雪印乳業, 食品化学研究本部, 副本部長
大浦 敏明 大阪市更生療育センター小児科, 所長
IGARASHI Hiroshi Assistant Professor of Pediatrics, Tohoku Univ. School of Medicine, 医学部小児科, 講師 (70101144)
ARAI Souichi Associate Professor of Aricultural Chemistry Tokyo Univ., School of Agriculture, 農学部農芸化学科, 助教授 (20011934)
AOKI Kikumaro Head of Research Development Department Aiiku Maternal and Child Health Center, 研究開発部, 部長 (20056584)
OURA Toshiaki Director of Osada Municipal Rehabilitation Center for the Disabled
KATAYAMA Sumio Director of Technical Research Laboratories Yukijirushi (Snow Bland) Milk Manufa
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥29,100,000 (Direct Cost: ¥29,100,000)
Fiscal Year 1986: ¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1985: ¥8,500,000 (Direct Cost: ¥8,500,000)
Fiscal Year 1984: ¥13,100,000 (Direct Cost: ¥13,100,000)
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| Keywords | PKU / Low-phenylalanine peptide / Low-phenylalanine milk / dietary treatment / PKU妊娠の胎児障害 / フェニルケトン尿症 / 低フェニルアラニンミルク / 低フェニルアラニンペプチド / 血清フェニルアラニン |
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| Research Abstract |
Low-phenylalanine (Phe) milk with amino acids as a nitrogen source is currently in common use for the treatment of phenylketonuria (PKU), however, more than a few of the patients with PKU dislike these special dietary products because of the bad taste and odor peculiar to some of the amino acids contained in them. The aim of our study is that a more palatable and dietric milk is prepared by using a low-Phe peptide as a protein source, because it has been reported that peptides do not have the unpleasant odor and are more easily aborbed.
Whey protein was used as the protein source. Pepsin was used to obtain the peptide containing phenylalanine (Phe) as the C-terminal and carboxypeptidase was used to shorten the peptide chain and to remove the Phe terminal. The hydrolysate was fractionated by a cellulofine GH-25m or charcoal column to obtain the low Phe peptides. Low-Phe peptide (LPP) milk was made at Yukijirushi (Snow Bland) Milk Manufacturing Co., Ltd.
Thirty-two normal healthy subjects
… More
and 12 children with PKU aged 11 years or over reported that they found the product less palatable than ordinary powdered milk for infant feeding but the product more palatable than the milk formula with amino acid powders as the main constituent. On the other hand, PKU children aged 3-10 years who had long been on amino acid-based milk formulas for PKU had no liking for the LPP-milk simply because they had gotten used to the taste and odor peculiar to amino acid powders. They could set used to the LPP product as well, chould they be placed on it early enough in life. Actually, both LPP-milk and low-Phe milk with amino acid mixture are acceptable to PKU infants aged 2 years or less because their sense of taste is still immature. Finally, LPP-milk has been used on 6 infants with PKU and a normally developed female PKU, who wants to become pregnant, for more than a year with great effectiveness in reducing the the serum Phe concentrations. Diarrhea is less frequent in the infants on LPP-milk than those on milk with amino acid mixture because the former has a lower osmolality than later. Less
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