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Study of activated carbon adsorbing anticancer drugs for chemotherapy of lymphnode metastasis and peritoneal metastasis.

Research Project

Project/Area Number 59870042
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionKyoto Prefectural University of Midicine (1985-1986)
Akita University (1984)

Principal Investigator

TAKAHASHI Toshio  Kyoto Prefectural University of Medicine, 医学部, 教授 (50079828)

Co-Investigator(Kenkyū-buntansha) YAMANE Tetsuro  Kyoto Prefectural University of Medicine, 第一外科学教室, 助手 (50166766)
YAMAGUCHI Toshiharu  Kyoto Prefectural University of Medicine, 第一外科学教室, 助手 (90111327)
SAKITA Masakazu  Kyoto Prefectural University of Medicine, 第一外科学教室, 講師 (40117883)
Project Period (FY) 1984 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1985: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1984: ¥3,600,000 (Direct Cost: ¥3,600,000)
Keywordsactivated carbon / anticancer drug / lymphnode metastasis / cancerous peritonitis / 腹膜播種性転移 / 微粒子活性炭 / 癌性腹膜炎 / MMC
Research Abstract

In this project new drug dosage form "activated carbon adsorbing anticancer drug" was produced. Activated carbon has numerous microposes that possesses great surface area and can adsorb or desorb the drug on the surface. When it is injected into tissues, it is adsorbed into the lymphatic capillaries and immediately reaches the regional lymph nodes. When it is injected into a cancerous pleural or abdominal cavity, it is adsorbed on cancer and serosal surface. Using these properties of the activated carbon, we have prepared activated carbon adsorbing Mitomycin C (MMC-CH) or Adriamicin (ADM-CH) for chemotherapy of lymphnodes metastasis and peritoneal metastasis. Animal experiments revealed that activated carbon adsorbing MMC or ADM was very effective on lymphnode metastasis and pleural or peritoneal metastasis.
MMC-CH and ADM-CH were applied to the patients with carcinoma of the stomach, breast and colon for the treatment of lymphnode metastasis. Beside the chemotherapy of lymphnode metastasis, lymphnodes stained in black by activated carbon were easily identified by surgeons,and many lymphnodes were dissected.
Forty five of 73 patients with carcinomatous peritonitis responded to MMC-CH. No serious adverse effect was observed.
As a result, activated carbon adsorbing anticancer drug was very useful for chemotherapy of lymphnode metastasis and pleural or peritoneal metastasis.

Report

(2 results)
  • 1986 Final Research Report Summary
  • 1985 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 萩原明於,高橋俊雄,上田忠,武田正人,李力行,水口直樹: 癌と化学療法. 10. 2558-2564 (1983)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 萩原明於,高橋俊雄,李力行,上田忠,武田正人: 秋田医学. 10. 419-422 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 高橋俊雄: 癌の臨床. 7. 1095-1102 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Toshio Takahashi: CRC Critical Reviews in Therapeutic Drug Carrier Systems.2. 245-274 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Akeo Hagiwara;Toshio Takahashi;et al.: Cancer. 59. 245-251 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Akeo Hagiwara;Toshio Takahashi;et al.: Anticancer Research. 6. 1161-1164 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 高橋俊雄,萩原明於: "内視鏡的胃癌リンパ節転移の化学療法,胃癌化学療法と内視鏡" 蟹書房, (1983)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 高橋俊雄: "再発防止を目的とした局所化学療法.The Latest Therapyシリーズ3.胃癌の外科-進行度別部位別にみた適正手術のあり方を中心に-" 医学教育出版社, 5 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Toshio Takahashi: "Emulsion and Activated Carbon in Cancer Chemotherapy." CRC Critical Reviews in Therapeutic Drug Carrier Systems.2. 245-274 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Akeo Hagiwara, Toshio Takahashi, et al.: "Chemotherapy for Carcinomatous Peritonitis and Pleuritis with MMC-CH, Mitomycin C Adsorbed on Activated Particles." Cancer. 59. 245-251 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Akeo Hagiwara, Toshio Takahashi, et al.: "Selective Delivery of High Levels of Mitomycin C to Peritoneal Carcinomatosis Using a New Dosage Form." Anticancer Research. 6. 1161-1164 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Akeo Hagiwara, Toshio Takahashi, et al.: "Anticancer Agents Adsorbed by Activated Carbon Particles, A New Form of Dosage Enhancing Efficacy on Lymphnodal Metastases." Anticancer Research. 6. 1005-1008 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 日本医師会雑誌. 93-2. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] 日本消化器外科学会雑誌. 18-5. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] 秋田医学. 11. (1985)

    • Related Report
      1985 Annual Research Report
  • [Publications] 最新医学. 40-9. (1985)

    • Related Report
      1985 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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