| Project/Area Number |
59870051
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | Niigata University |
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Principal Investigator |
SHIMOJI Koki Niigata University, School of Medicine, Professor, 医学部, 教授 (30040158)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Hiroshi Niigata University, School of Medicine, Assistant, 医学部, 助手 (90168831)
HASHIBA Masao Niigata University, School of Medicine, Lecturer, 医学部附属病院, 講師 (30108047)
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1986: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1985: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1984: ¥5,700,000 (Direct Cost: ¥5,700,000)
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| Keywords | Catheter electrode / Regional blood flow / Oxygen pressure / Evoked spinal cord potential / 硬膜外腔 / 電解式水素クリアランス / 脊髄背面電位 |
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| Research Abstract |
In order to monitor the functions of central nerve system under anesthesia and intensive care, a catheter electrode with simultaneous measurement system of regional blood flow, oxygen pressure and electrcal activity was developed. Three platinum-iridium electrodes were arranged at the tip of the polyperfluoroethylene epidural catheter with outer and inner diameters of 0.8 and 0.5 mm, respectively. One of them was used for measurements of both regional bloof flow and oxgen pressure by inversion of its polarity. The other two electrodes were used for recording of electrical activity. Regional blood flow was calculated from the clearance of hydrogen generated by electrolysis. Our preliminary experiment has demonstrated that regional spinal cord blood flow has a linear correlationship with regional epidural blood flow (rEBF) in response to changes in arterial carbon dioxide tension and mean arterial pressure. The catheter electrode was inserted into the posterior epidural space, and rEBF, oxygen pressure and evoked spinal cord potential (ESCP) were measured and recorded under neuroleptanesthesia (NLA). An increase of rEBF was observed when 2% halothane was administrated during NLA. The segmental ESCP which consists of an initial positive spike (P1) followed by a sharp negative- (N1) and a slow positive (P2) wave could also be recorded simultaneously. Reproducibility of measurement of oxygen pressure was not enough to obtain reliable values. From the results, although further studies were needed for improvement of oxygen pressure measure, it is indicated that the function of spinal cord in terms of above three parameters could be monitored without puncture of dura by application of the catheter electrode system.
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