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Mechanisms of Regulation of Biosynthesis of Blood Sugar- and Blood Pressure-Lowering Peptides

Research Project

Project/Area Number 60065004
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

OKAMOTO Hiroshi  Tohoku University School of Medicine, Department of Biochemistry, Professor & Chairman, 医学部, 教授 (60025632)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Hiroshi  Tohoku University School of Medicine, Department of Biochemistry, Associate Prof, 医学部, 助教授 (00115198)
Project Period (FY) 1985 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥223,000,000 (Direct Cost: ¥223,000,000)
Fiscal Year 1989: ¥23,000,000 (Direct Cost: ¥23,000,000)
Fiscal Year 1988: ¥19,000,000 (Direct Cost: ¥19,000,000)
Fiscal Year 1987: ¥21,000,000 (Direct Cost: ¥21,000,000)
Fiscal Year 1986: ¥79,000,000 (Direct Cost: ¥79,000,000)
Fiscal Year 1985: ¥81,000,000 (Direct Cost: ¥81,000,000)
KeywordsVIP Gene / Cyclic AMP / Phorbol Ester-Responsive Element / Peptidylglycine alpha-Amidating Enzyme / Pancreatic Polypeptide Gene / Mosaic Evolution / rig (Rat Insulinoma Gene) / reg (Regenerating Gene) / Pancreatic beta-Cells of the Islets of Langerhans / ペプチドC末端αーアミド化酵素 / reg遺伝子 / rig遺伝子 / pancreatic stone protein / pancreatic thread protein / 酸素添加酵素 / cyclic AMP@phorbol ester-responsive element / rig / housekeeping gene / oncogene / reg / インスリーノーマ遺伝子 / アンチセンスオリゴヌクレオチド / nuclear oncogene / 再生膵B細胞 / pancreatic polypeptide / TATA box / プロモーター / prepro VIP mRNA / rig(rat insulinoma gene) / インスリノーマ / 種間保存 / genomic ライブラリー / VIP / PHM-27遺伝子 / インスリン / PHM-27mRNA / 膵B細胞腫 / Phorbol esters / Vasoactive Intestinal Peptide(VIP)
Research Abstract

1.(1) The organization and primary structure of the gene coding for human vasoactive intestinal peptide (VIP) were determined. (2) The VIP gene was assigned to q26->27 of human chromosome 6. (3) The VIP gene expression was found to be induced by cyclic AMP and phorbol esters, and cisacting DNA hements and a transacting nuclear factor that mediate the induction were identified. (4) Peptidylglycine alpha-amidating sonooxygenase, an enzyme involved in the final step of VIP biosynthesis, was purified from rat brain and equine serum, and an intermediate of the alpha-amidating reaction was identified. (5) Structural analyses of the cDNA and the gene for pancreatic polypeptide, another carboxyamidated peptide, revealed that the blend of conservation and divergence in the polypeptide precursor has been generated through "mosaic evolution" of the gene.
2.(1) A novil gene encoding a 145-amino acid protein was identified in screening a rat insulinona-derived cDNA library, and designated rig (rat i … More nsulinona gene). (2) rig was found to be expressed at high levels in a variety of human tumors, including insulinomas, and also in proliferating normal cells. (3) The organization and structure of human genomic rig and its pseudogenes were determined. (4) The rig protein was found to accumulate in the nucleus at the S phase of the cell cycle, and the DNA synthesis in insulinona cells was inhibited by microinjection of antisense oligonucleotides complementary to rig mRNA, indicating that rig may be involved in cell growth and replication. (5) In screening a rat regenerating islet-derived cDNA library, a novel gene, reg (regenerating gene), was identified: reg encoded a 165-amino acid secretory protein and was expressed during the regeneration of insulin-producing beta-cells. (6) The human reg cDNA and gene were also isolated and their complete nucleotide sequences were determined. (7) The rig and reg genes were built into expression vectors to drive Escherichia coli and yeast to synthesize rig and reg proteins. The higher-order structure of the recombinant reg protein was characterized. Less

Report

(6 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • 1986 Annual Research Report
  • 1985 Annual Research Report
  • Research Products

    (148 results)

All Other

All Publications (148 results)

  • [Publications] Okamoto.H.: "Molecular Basis of Experimental Diabetes:Degeneration,Oncogenesis and Regeneration of Pancreatic B-Cells of Islets of Langerhans." Bio Essays(Cambridge University Press). 2. 15-21 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto,H.: "The Role of Poly(ADP-ribose)Synthetase in the Development of Insulin-Dependent Diabetes and Islet B-Cell Regeneration." Biomed.Biochim.Acta. 44. 15-20 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamagami,T.,Miwa,A.,Takasawa,S.,Yamamoto,H.and Okamoto,H.: "Induction of Rat Pancreatic B-Cell Tumours by the Combined Administration of Streptozotocin or Alloxan and Poly(Adenosine Diphosphate Ribose)Synthetase Inhibitors." Cancer Research. 45. 1845-1849 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohsawa,K.,Hayakawa,Y.,Nishizawa,M.,Yamagami,T.,Yamamoto,H.and Okamoto,H.: "Synergistic Stimulation of VIP/PHM-27 Gene Expression by Cyclic AMP and Phorbol Esters in Human Neuroblastoma Cells" Biochem.Biophys.Res.Commun.132. 885-891 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Nishizawa,M.,Hayakawa,Y.,Yanaihara,N.and Okamoto,H.: "Nucleotide Sequence Divergence and Functional Constraint in VIP Precursor mRNA during Evolution between Human and Rat." FEBS Letters. 183. 55-59 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Mizuki,K.,Nose,K.,Okamoto,H.,Tsuchida,N.,and Hayashi,K.: "Amplification of c-Ki-ras Gene and Aberrant Expression of cmyc in WI-38 Cells Transformed in vitro by γ-Irradiation." Biochem,Biophys.Res.Commun.128. 1037-1043 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamamoto,H.,Nata,K.,Okamoto,H.: "Mosaic Evolution of Prepropancreatic Polypeptide." J.Biol.Chem.261. 6156-6159 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takasawa,S.,Yamamoto,H.,Terazono,K.and Okamoto,H.: "Novel Gene Activated in Rat Insulinomas." Diabetes. 35. 1178-1180 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yanaihara,C.,Hashimoto,Y.,Takeda,Y.,Kato,I.,Track,N.S.,Nokihara,K.,Iwanaga,T.,Fujita,T.,Okamoto,H.and Yamaihara,N.: "PHI Structural Requirements for Potentiation of Glucose-Induced Insulin Release." Peptides. 7. 83-88 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Inoue,C.,Shiga,K.,Takasawa,S.,Kitagawa,M.,Yamamoto,H.and Okamoto,H.: "Evolutionary Conservation of the Insulinoma Gene rig and Its Possible Function." Proc.Natl.Acad.Sci.U.S.A.84. 6659-6662 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Terazono,K.,Yamamoto,H.,Takasawa,S.and Okamoto,H.: "A Novel Gene Activated in Regenerating Islets." J.Biol.Chem.263. 2111-2114 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yonekura,H.,Nata,K.,Watanabe,T.,Kurashina,Y.,Yamamoto,H.and Okamoto,H.: "Mosaic Evolution of Prepropancreatic Polypeptide.II.STRUCTURAL CONSERVATION AND DIVERGENCE IN PANCREATIC POLYPEPTIDE GENE." J.Biol.Vhem.263. 2990-2997 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamagami,T.,Ohsawa,K.,Nishizawa,M.,Inoue,C.,Gotoh,E.,Yanaihara,N.,Yamamoto,H.and Okamoto,H.: "Complete Nucleotide Sequence of Human Vasoactive Intestinal Peptide/PHM-27 Gene and Its Inducible Peomoter." Ann.New York Acad.Sci.527. 87-102 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Inoue,C.,Igarashi,K.,Kitagawa,M.,Terazono,K.,Obata,K.,Iwata,K.,Yamamoto,H.and Okamoto,H.: "Expression of the Insulinoma Gene rig during Liver Regeneration and in Primary Cultured Hepetocytes." Biochem.Biophys.Res.Commun.150. 1302-1308 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gotoh,E.,Yamagami,T.,Yamamoto,H.and Okamoto,H.: "Chromosomal Assignment of Human VIP/PHM-27 Gene to 6q26→27 Region by Spot Blot Hybridization and in situ Hybrdization." Biochem.Int.17. 555-562 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yonemura,Y.,Takashima,T.,Matsuda,Y.,Miwa,K.,Sugiyama,K.,Miyazaki,I.,Yamamoto,H.and Okamoto,H.: "Induction of Islet B-Cell Regeneration in Partially Pancreatectomized Rats by Poly(ADP-ribose)Synthetase Inhibitors." Int.J.Pancreatol.3. 73-82 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Noguchi,M.,Takahashi,K.and Okamoto,H.: "Characterization of Peptidylglycine α-Amidating Activities in Rat Pituitary,Brain and Small Intestine Using Glycine-Extended C-Terminal Analogues of Vasoactive Intestinal Peptide as a Substrate." Tohoku J.Exp.Med.156. 191-207 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Inoue,C.,Yamamoto,H.,Nakamura,T.,Ichihara,A. and Okamoto,H.: "Nicotinamide Prolongs Survival of Primary Cultured Hepatocytes without Involving Loss of Hepatocyte-Specific Functions." J.Biol.Chem.264. 4747-4750 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Noguchi,M.,Takahashi,K.and Okamoto,H.: "Rat Peptidylglycine α-Amidating Enzyme:The Relation between Activities at Neutral and Alkaline pH Values." Arch.Biochem.Biophys.275. 505-513 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Leffert,J.D.,Newgard,C.,Okamoto,H.,Miburn,J.L.and Luskey,K.: "Rat Amylin:Cloning and Tissue-Specific Expression in Pancreatic Islets." Proc.Natl.Acad.Sci.U.S.A.86. 3127-3130 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sugawara,A.,Nata,K.,Inoue,C.,Takasawa,S.,Yamamoto,H.and Okamoto,H.: "Nucleotide Sequence Determination of Mouse,Chicken and Xenopus laevis rig cDNAs:The rig-Encoded Protein Is Extremely Conserved during Vertebrate Evolution." Biochem.Biophys.Res.Commun.166. 1501-1507 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Watanabe,T.,Yonekura,H.,Terazono,K.Yamamoto,H. and Okamoto,H.: "Complete Nucleotide Sequence of Human reg Gene and Ist Expression in Normal and Tumoral Tissues.The reg Protein,Pancreatic Stone Protein,and Pancreatic Thread Protein Are One and the Same Product of the Gene." J.Biol.Chem.265. inpress (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tajima,M.,Iida,T.,Yoshida,S.,Komatsu,K.,Namba,R.,Yanagi,M.,Noguchi,M.and Okamoto,H.: "The Reaction Product of Peptidylglycine α-Amidating Enzyme Is a Hydroxyl Derivative at α-Carbon of the Carboxyl Terminal Glycine." J.Biol.Chem.265. inpress (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shiga,K.,Yamamoto,H.and Okamoto,H.: "Isolation and Characterization of Human rig and Its Pseudogenes:The Functional Gene Has Features Characteristic of Housekeeping Genes." Proc.Natl.Acad.Sci.U.S.A.87. inpress (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Terazono,K.,Uchiyama,Y.,Ide,M.,Watanabe,T.,Yonekura,H.Yamamoto,H.and Okamoto,H.: "Expression of reg Protein in Rat Regenerating Islets and Its Co-Localization with Insulin in the Beta Cell Secretory Granules." Diabetologia. 33. inpress (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hasegawa,S.,Terazono,K.,Nata,K.,Takada,T.,Yamamoto,H.and Okamoto,H.: "Nucleotide Sequence Determination of Chicken Glucagon Precursor cDNA:Chicken Preproglucagon Does Not Contain Glucagonlike Peptide II." FEBS Letters. inpress (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kato,I.,Yonekura,H.,Yamamoto,H.and Okamoto,H.: "Cloning and Expression of Pituitary α-Amidating Enzyme cDNA:Variant Lacking Transmembrane Domain." Science. submitted (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Itoh,T.,Tsuzuki,H.,Katoh,T.,Teraoka,H.Matsumoto,K.Yoshida,N.,Terazono,K.,Watanabe,T.,Yonekura,H.,Yamamoto,H.and Okamoto,H.: "Isolation and Characterization of Human and Rat reg Proteins Produced in Saccharomyces Cerevisiae." J.Biol.Chem.submitted (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto,H.,Yamamoto,H.and Yonemura,Y.: "Poly(ADP-ribose)Synthetase Inhibitors Induce Islet Regeneration in Partially Depancreatized Rats.In“ADP-Ribosylation of Proteins"(Althaus,F.R.,Hilz,H.and Shall,S.eds)" Springer-Verlag,Berlin,Heiderberg, 410-416 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto,H.,Yamamoto,H.,Yamagami,T.and Takasawa,S.: "Mechanism of B-Cell Injury and Its Prevention in IDDM-A Molecular Approach.In“Diabetes 1985"(Serrano-Rios,M.and Lefebvre,P.J.,eds)" Elsevier Science Publishers, 509-512 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohsawa.K.,Yamagami,T.,Nishizawa,M.,Inoue,C.,Gotoh,E.,Yamamoto,H.and Okamoto,H.: "Structure and Expression of Human Vasoactive Intestinal Peptide/PHM-27 Gene.In“Hormonal Regulation of Gene Expression"(Edited by Institute of Endocrinology,Gunma University)" Center for Academic Publications Japan,Tokyo VNU Science Press,Utrecht, 169-181 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohgaku,S.,Morioka,H.Sawa,T.,Yano,S.,Yamamoto,H.,Okamoto,H.and Tochino,Y.: "Restriction Fragment Length Polymorphism(RELP) at the Locus of Insulin Gene in“NON" Mice,a New Animal Model for Non-Obese NIDDM.In “Best Approach to the Ideal Therapy of Diabetes Mellitus"" Excerpta Medica,Amsterdam(Shigeta,Y.,Lobovitz,H.E.,Gerich,J.E.and Malaisse,W.J.,eds), 133-136 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto,H.,Yamamoto,H.,Takazawa,S.,Inoue,C.,Terazono,K.,Shiga,K.and Kitagawa,M.: "Molecular Mechanism of Degeneration,Oncogenesis and Regeneration of Pancreatic B-Cells of Islets of Langerhans.In“Frontiers of Diabetes Research.Lessons from Animal Diabetes II"" John Libbey & Company,London(Shafrir,E.and Renold,A.E.,eds), 149-157 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohgaku,S.,Morioka,H.,Sawa,T.,Yano,S.,Yamamoto,H.,Okamoto,H.and Tochino,Y.: "Reduced Expression and Restriction Fragment Length Polymorphism of Insulin Gene in NON Mice,a New Animal Model for Non-Obese,Non-Insulin-Dependent Diabetes.In“Frontiers of Diabetes Research.Lessons from,Animal Diabetes Research,Lessous from Animal Piabetes II"" John Libbey & Company,London(Shafrir,E.and Renold,A.E.,eds), 319-323 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto,H.: "rig and reg:Novel Genes Activated in Insulinomas and Regenerating Islets.In“Diabetes 1988"(Larkins,R.G.et al.,eds)" Excerpta Media,Amsterdam, 55-62 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto,H.: "“Molecular Biology of the Islets of Langerhans"(Edited by Okamoto,H.)" Cambridge University Press,Cambridge, 352 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto,H.: "Introductory Overview.In“Molecular Biology of the Islets of Langerhans"(Okamoto,F.,ed)" Cambridge University Press,Cambridge, 1-5 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto,H.: "The Molecular Basis of Experimental Diabetes.In“Molecular Biology of the Islets of Langerhans"(Okamoto,H.,ed)" Cambridge University Press,Cambridge, 209-231 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Itoh,N.: "The Tranlational Control of Proinsulin Biosynthesis.In“Molecular Biology of the Islets of Langerhans"(Okamoto,H.,ed)" Cambridge University Press,Cambridge, 49-65 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamamoto,H.,Yonekura,H.and Nata,K.: "The Mosaic Evolution of the Pancreatic Polypeptide Gene.In“Molecular Biology of the Islets of Langerhans"(Okamoto,H.,ed)" Cambridge University Press,Cambridge, 107-124 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamagami,T.: "The Structure and Expression of Genes of Vasoactive Intestinal Peptide and Related Peptides.In“Molecular Biology of the Islets of Langerhans"(Okamoto,H.,ed)" Cambridge University Press,Cambridge, 125-143 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takasawa,S.,Inoue,C.,Shiga,K.and Kitagawa,M.: "A Novel Gene,rig,Avtivated in Insulinomas.In“Molecular Biology of the Islets of Langerhans"(Okamoto,H.,ed)" Cambridge University Press,Cambridge, 287-300 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Terazono,K.,Watanabe,T.and Yonemura,Y.: "A Novel Gene,reg,Expressed in Insulinomas.In“Molecular Biology of the Islets of Langerhans"(Okamoto,H.,ed)" Cambridge University Press,Cambridge, 301-313 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto, H.: "Molecular Basis of Experimental Diabetes: Degeneration, Oncogenesis and Regeneration of Pancreatic B-Cells of Islets of Langerhans." BioEssays (Cambridge University Press). 2. 15-21 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto, H.: "The Role of Poly(ADP-ribose) Synthetase in the Development of Insulin-Dependent Diabetes and Islet B-Cell Regeneration." Biomed. Biochim. Acta. 44. 15-20 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamagami, T., Miwa, A., Takasawa, S., Yamamoto, H. and Okamoto, H.: "Induction of Rat Pancreatic B-Cell Tumors by the Combined Administration of Streptozotocin of Alloxan and Poly(Adenosine Diphosphate Ribose) Synthetase Inhibitors." Cancer Research. 45. 1845-1849 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohsawa, K., Hayakawa, Y., Nishizawa, M., Yamagami, T., Yamamoto, H., Yanaihara, N. and Okamoto, H.: "Synergistic Stimulation of VIP/PHM-27 Gene Expression by Cyclic AMP and Phorbol Esters in Human Neuroblastoma Cells." Biochem. Biophys. Res. Commun.132. 885-891 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Nishizawa, M., Hayakawa, Y., Yanaihara, N. and Okamoto, H.: "Nucleotide Sequence Divergence and Functional Constraint in VIP Precursor mRNA Evolution between Human and Rat." FEBS Lett.183. 55-59 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Mizuki, K., Nose, K., Okamoto, H., Tsuchida, N. and Hayashi, K.: "Amplification of c-Ki-ras Gene and Aberrant Expression of c-myc in WI-38 Cells Transformed in vitro by gamma-Irradiation." Biochem. Biophys. Res. Commun.128. 1037-1043 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamamoto, H., Nata, K. and Okamoto, H.: "Mosaic Evolution of Prepropancreatic Polypeptide." J. Biol. Chem.261. 6156-6159 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takasawa, S., Yamamoto, H., Terazono, K. and Okamoto, H.: "Novel Gene Activated in Rat Insulinomas." Diabetes. 35. 1178-1180 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yanaihara, C., Hashimoto, Y., Takeda, Y., Kato, I., Track, N.S., Nokihara, K., Manaka, H., Iwanaga, T., Fujita, T., Okamoto, H. and Yanaihara, N.: "PHI Structural Requirements for Potentiation of Glucose-Induced Insulin Release." Peptides. 7. 83-88 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Inoue, C., Shiga, K., Takasawa, S., Kitagawa, M., Yamamoto, H. and Okamoto, H.: "Evolutionary Conservation of the Insulinoma Gene rig and Its Possible Function." Proc. Natl. Acad. Sci. U.S.A.84. 6659-6662 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Terazono, K., Yamamoto, H., Takasawa, S. and Okamoto, H.: "A Novel Gene Activated in Regenerating Islets." J. Biol. Chem.263. 2111-2114 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yonekura, H., Nata, K., Watanabe, T., Kurashina, Y., Yamamoto, H. and Okamoto, H.: "Mosaic Evolution of Prepropancreatic Polypeptide. II. STRUCTURAL CONSERVATION AND DIVERGENCE IN PANCREATIC POLYPEPTIDE GENE." J. Biol. Chem.263. 2990-2997 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamagami, T., Ohsawa, K., Nishizawa, M., Inoue, C., Gotoh, E., Yanaihara, N., Yamamoto, H. and Okamoto, H.: "Complete Nucleotide Sequence of Human Vasoactive Intestinal Peptide/PHM-27 Gene and Its Inducible Promoter." Ann. New York Acad. Sci.527. 87-102 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Inoue, C., Igarashi, K., Kitagawa, M., Terazono, K., Obata, K., Iwata, K., Yamamoto, H. and Okamoto, H.: "Expression of the Insulinoma Gene rig during Liver Regeneration and in Primary Cultured Hepatocytes." Biochem. Biophys. Res. Commun.150. 1302-1308 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gotoh, E., Yamagami, T., Yamamoto, H. and Okamoto, H.: "Chromosomal Assignment of Human VIP/PHM-27 Gene to 6q26->27 Region by Spot Blot Hybridization and in situ Hybridization." Biochem. Int.17. 555-562 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yonemura, Y., Takashima, T., Matsuda, Y., Miwa, K., Sugiyama, K., Miyazaki, I., Yamamoto, H. and Okamoto, H.: "Induction of Islet B-Cell Regeneration in Partially Pancreatectomized Rats by Poly(ADP-ribose) Synthetase Inhibitors." Int. J. Pancreatol.3. 73-82 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Noguchi, M., Takahashi, K. and Okamoto, H.: "Characterization of Peptidylglycine alpha-Amidating Activities in Rat Pituitary, Brain and Small Intestine Using Glycine-Extended C-Terminal Analogues of Vasoactive Intestinal Peptide as Substrate." Tohoku J. Exp. Med.156. 191-207 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Inoue, C., Yamamoto, H., Nakamura, T., Ichihara, A. and Okamoto, H.: "Nicotinamide Prolongs Survival of Primary Cultured Hepatocytes without Involving Loss of Hepatocyte-Specific Functions." J. Biol. Chem.264. 4747-4750 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Noguchi, M., Takahashi, K. and Okamoto, H.: "Rat Peptidylglycine alpha-Amidating Enzyme: The Relation between Activities at Neutral and Alkaline pH Values." Arch. Biochem. Biophys.275. 505-513 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Leffert, J.D., Newgard, C., Okamoto, H., Milburn, J.L. and Luskey, K.: "Rat Amylin: Cloning and Tissue-Specific Expression in Pancreatic Islets." Proc. Natl. Acad. Sci. U.S.A.86. 3127-3130 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sugawara, A., Nata, K., Inoue, C., Takasawa, S., Yamamoto, H. and Okamoto, H.: "Nucleotide Sequence Determination of Mouse, Chicken and Xenopus laevis rig cDNAs: the rig-Encoded Protein Is Extremely Conserved during Vertebrate Evolution." Biochem. Biophys. Res. Commun.166. 1501-1507 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Watanabe, T., Yonekura, H., Terazono, K., Yamamoto, H. and Okamoto, H.: "Complete Nucleotide Sequence of Human reg Gene and Its Expression in Normal and Tumoral Tissues. The reg Protein, Pancreatic Stone Protein, and Pancreatic Thread Protein Are One and the Same Product of the Gene." J. Biol. Chem.265. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tajima, M., Iida, T., Yoshida, S., Komatsu, K., Namba, R., Yanagi, M., Noguchi, M. and Okamoto, H.: "The Reaction Product of Peptidylglycine alpha-Amidating Enzyme Is a Hydroxyl Derivative at alpha-Carbon of the Carboxyl Terminal Glycine." J. Biol. Chem.265. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shiga, K., Yamamoto, H. and Okamoto, H.: "Isolation and Characterization of Human rig and Its Pseudogenes: The Functional Gene Has Features Characteristic of Housekeeping Genes." Proc. Natl. Acad. Sci. U.S.A.87. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Terazono, K., Uchiyama, Y., Ide, M., Watanabe, T., Yonekura, H., Yamamoto, H. and Okamoto, H.: "Expression of reg Protein in Rat Regenerating Islets and Its Co-Localization with Insulin in the Beta Cell Secretory Granules." Diabetologia. 33. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hasegawa, S., Terazono, K., Nata, K., Takada, T., Yamamoto, H.: "Glucagon Precursor cDNA: Chicken Preproglucagon Does Not Con- and Okamoto, H., Nucleotide Sequence Determination of Chicken tain Glucagon-like Peptide II." FEBS Lett.(1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kato, I., Yonekura, H., Yamamoto, H. and Okamoto, H.: "Cloning and Expression of Pituitary alpha-Amidating Enzyme cDNA: Variant Lacking Transmembrane Domain." Science. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Itoh, T., Tsuzuki, H., Katoh, T., Teraoka, H., Matsumoto, K., Yoshida, N., Terazono, K., Watanabe, T., Yonekura, H., Yamamoto, H. and Okamoto, H.: "Isolation and Characterization of Human and Rat reg Proteins Produced in Saccharomyces Cerevisiae." J. Biol. Chem.(1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto, H., Yamamoto, H. and Yonemura, Y.: ADP-Ribosylation of Proteins (Althaus, F.R., Hilz, H. and Shall, S., eds). Springer-Verlag, Berlin, Heiderberg, 410-416 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto, H., Yamamoto, H., Yamagami, T. and Takasawa, S.: Diabetes 1985 (Serrano-Rios, M. and Lefebvre, P.J., eds). Elsevier Science Publishers, 509-512 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohsawa, K., Yamagami, T., Nishizawa, M., Inoue, C., Gotoh, E., Yamamoto, H. and Okamoto, H.: Hormonal Regulation of Gene Expression (Edited by Institute of Endocrinology, Gunma University). Center for Academic Publications Japan, Tokyo, 169-181 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohgaku, S., Morioka, H., Sawa, T., Yano, S., Yamamoto, H., Okamoto, H. and Tochino, Y.: Best Approach to the Ideal Therapy of Diabetes Mellitus (Shigeta, Y., Lebovitz, H.E., Gerich, J.E. and Malaisse, W.J., eds). Excerpta Medica, Amsterdam, 133-136 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto, H., Yamamoto, H., Takasawa, S., Inoue, C., Terazono, K., Shiga, K. and Kitagawa, M.: Frontiers of Diabetes Research. Lessons from Animal Diabetes II (Shafrir, E. and Renold, A.E., eds). John Libbey & Company, London, 149-157 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohgaku, S., Morioka, H., Sawa, T., Yano, S., Yamamoto, H., Okamoto, H. and Tochino, Y.: Frontiers of Diabetes Research. Lessons from Animal Diabetes II (Shafrir, E. and Renold, A.E., eds). John Libbey & Company, London, 319-323 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto, H.: Diabetes 1988 (Larkins, R.G. et al., eds). Excerpta Medica, Amsterdam, 55-62 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto, H.: Molecular Biology of the Islets of Langerhans. Cambridge University Press, Cambridge, 1-352 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto, H.: Molecular Biology of the Islets of Langerhans (Okamoto, H., ed). Cambridge University Press, Cambridge, 1-5 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okamoto, H.: Molecular Biology of the Islets of Langerhans (Okamoto, H., ed). Cambridge University Press, Cambridge, 209-231 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Itoh, N.: Molecular Biology of the Islets of Langerhans (Okamoto, H., ed). Cambridge University Press, Cambridge, 49-65 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamamoto, H., Yonekura, H. and Nata, K.: Molecular Biology of the Islets of Langerhans (Okamoto, H., ed). Cambridge University Press, Cambridge, 107-124 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamagami, T.: Molecular Biology of the Islets of Langerhans (Okamoto, H., ed). Cambridge University Press, Cambridge, 125-143 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takasawa, S., Inoue, C., Shiga, K. and Kitagawa, M.: Molecular Biology of the Islets of Langerhans (Okamoto, H., ed). Cambridge University Press, Cambridge, 287-300 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Terazono, K., Watanabe, T. and Yonemura, Y.: Molecular Biology of the Islets of Langerhans (Okamoto, H., ed). Cambridge University Press, Cambridge, 301-313 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Inoue C.et al.: "Nicotinamide prolongs survival of primary cultured hepatocytes without involving loss of hepatocyte-specific functions" J.Biol.Chem.264. 4747-4750 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Noguchi,M.et al.: "Rat peptidylglycine α-amidating enzyme:the relation between activities at neural and alkaline pH values" Arch.Biochem.Biophys.275. 505-513 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Leffert,J.D.et al.: "Rat amylin:cloning and tissue-specific expression in pancreatic islets." Proc.Natl.Acad.Sci.U.S.A.86. 3127-3130 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sugawara,A.et al.: "Nucleotide sequence determination of mouse,chicken and Xenopus laevis rig cDNAs:the rig-encoded protein is extremely conserved during vertebrate evolution" Biochem.Biophys.Res.Commun.166. 1501-1507 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Watanabe,T.et al.: "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues.The reg protein,pancreatic stone protein,and pancreatic thread protein are one and the same product of the gene." J.Biol.Chem.265. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tajima,M.et al.: "The reaction product of peptidylglycine α-amidating enzyme is a hydroxyl derivative at α-carbon of the carboxyl terminal glycine." J.Biol.Chem.265. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Shiga,K.et al.: "Isolation and characterization of human rig and its pseudogenes:the functional gene has features characteristic of housekeeping genes." Proc.Natl.Acad.Sci.U.S.A.87. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Terazono,K.et al.: "Expression of reg protein in rat regenerating islets and its colocalization with insulin in the β-cell secretory granules" Diabetologia. 33. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kato,I.et al.: "Cloning and expression of pituitary α-amidating enzyme cDNA:variant lacking transmembrane domain" Science. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ito,T.et al.: "Isolation and characterization of human and rat reg proteins produced in Saccharomyces cerevisiae" J.Biol.Chem.(1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hasegawa,S.et al.: "Nucleotide sequence determination of chicken glucagon precursor cDNA:chicken preproglucagon does not contain glucagon-like peptide II." FEBS Lett.(1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Okamoto,H.: "rig and reg:novel genes activated in insulinomas and in regenerating islets.“Diabetes 1988"(Larkins,R.G.et al.,eds)" Excerpta Medica,Amsterdam, 1243 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Okamoto,H.: "The molecular basis of experimental diabetes.“Molecular Biology of the Islets of Langerhans"(Okamoto,H.ed.)" Cambridge University Press,Cambridge, 352 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yamamoto,H.,et al.: "The mosaic evolution of the pancreatic polypeptide gene.“Molecular Biology of the Islets of Langerhans"(Okamoto,H.ed.)" Cambridge University Press,Cambridge, 352 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Itoh,N.: "The translational control of proinsulin synthesis by glucose.“Molecular Biology of the Islets of Langerhans"(Okamoto,H.ed.)" Cambridge University Press,Cambridge, 352 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yamagami,T.: "The structure and expression of genes of vasoactive intestinal peptide and related peptides.“Molecular Biology of the Islets of Langerhans"(Okamoto,H.ed.)" Cambridge University Press,Cambridge, 352 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Yamagami;K.Ohsawa;M.Nishizawa;C.Inoue;E.Gotoh;N.Yanaihara;H.Yamamoto;H.Okamoto: Ann.N.Y.Acad.Sci.527. 87-102 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Terazono;H.Yamamoto;S.Takasawa;K.Shiga;Y.Yonemura;Y.Tochino;H.Okamoto: J.Biol.Chem.263. 2111-2114 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Yonekura;K.Nata;T.Watanabe;Y.Kurashina;H.Yamamoto;H.Okamoto: J.Biol.Chem.263. 2990-2997 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] C.Inoue;H.Yamamoto;T.Nakamura;A.Ichihara;H.Okamoto: J.Biol.Chem.264. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] E.Gotoh;T.Yamagami;H.Yamamoto;H.Okamoto: Biochemistry International. 17. 555-562 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] C.Inoue;K.Igarashi;M.Kitagawa;K.Terazono;K.Obata;K.Iwata;H.Yamamoto;H.Okamoto: Biochem.Biophys.Res.Commun.150. 1302-1308 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Yonemura;T.Takashima;Y.Matsuda;K.Miwa;K.Sugiyama;I.Miyazaki;H.yamamoto;H.Okamoto: International Journal of Pancreatology. 3. 73-82 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] M.Noguchi;K.Takahashi;H.Okamoto: Tohoku J.Exp.Med.156. 191-207 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] C.B.Newgard;S.Hughes;L.Chen;H.Okamoto;J.Milburn: Diabetes. 38. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] J.D.Leffert;C.B.Newgard;H.Okamoto;K.L.Luskey: Proc.Natl.Acad.Sci.U.S.A.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Ohsawa;T.Yamagami;M.Nishizawa;H.Yamamoto;H.Okamoto: FEBS Lett.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Shiga;H.Yamamoto;H.Okamoto: J.Biol.Chem.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Watanabe;H.Yonekura;K.Terazono;K.Shiga;T.Abo;H.Yamamoto;H.Okamoto: J.Biol.Chem.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Itoh;H.Teraoka;N.Yoshida;H.Yamamoto;H.Okamoto: J.Biol.Chem.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Okamoto;H.Yamamoto;S.Takasawa;C.Inoue;K.Terazono;K.Shiga;M.Kitagawa: "Frontiers in Diabetes Research" John Libbey & Co.Ltd.,London, 560 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Okamoto: "Molecular Biology of the Islets of Langerhans(Editor,H.Okamoto)" Cambridge University Press,Cambridge, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Yamamoto;H.Yonekura;K.Nata: "Molecular Biology of the Islets of Langerhans(Editor,H.Okamoto)" Cambridge University Press,Cambridge, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] N.Itoh: "Molecular Biology of the Islets of Langerhans(Editor,H.Okamoto)" Cambridge University Press,Cambridege, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Yamagami: "Molecular Biology of the Islets of Langerhans(Editor,H.Okamoto)" Cambridge University Press,Cambridge, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] S.Takasawa;C.Inoue;K.Shiga;M.Kitagawa: "Molecular Biology of the Islets of Langerhans(Editor,H.Okamoto)" Cambridge University Press,Cambridge, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Terazono;T.Watanabe;Y.Yonemura: "Molecular Biology of the Islets of Langerhans(Editor,H.Okamoto)" Cambridge University Press,Cambridge, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] C. Inoue,K. Shiga, S. Takasawa, H. Yamamoto, and H. Okamoto: Proc. Natl. Acad. Sci. U.S.A.84. 6659-6662 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] C. Inoue, K. Igarashi, M. Kitagawa, K. Terazono, K. Obata, K. Iwata, H. Yamamoto, and H. Okamoto: Biochem. Biophys. Res. Commun.150. 1302-1308 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] K. Terazono, H. Yamamoto, S. Takasawa, K. Shiga, Y. Yonekura, Y. Tochino, and H. Okamoto: J. Biol. Chem.263. 2111-2114 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] H. Yonekura, K. Nata, T. Watanabe, Y. Kurashina, H. Yamamoto, and H. Okamoto: J. Biol. Chem.263. 2990-2997 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] T. Yamagami, K. Ohsawa, M. Nishizawa, C. Inoue, E. Gotoh N. Yanaihara, H. Yamamoto, and H. Okamoto: Ann. N.Y. Acad. Sci.(1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 山本博,高澤伸,井上千代子,志賀清人,寺薗公雄,北川元生,山上孝司,岡本宏: 現代化学. 12. 52-60 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] S. Ohgaku, H. Morioka, T. Sawa, S. Yano, H. Yamamoto, H. Okamoto and Y. Tochino: "Best Approach to the Ideal Therapy of Diabetes Mellitus" Excerpta Medica, 754 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] H. Okamoto, H. Yamamoto, S. Takasawa, C. Inoue, K. Terazono, K. Shiga, and M. Kitagawa: "Frontiers in Diabetes Reaearch" John Libbey & Co. Ltd., (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] K. Ohsawa, T. Yamagami, M. Nishizawa, C. Inoue, E. Gotoh, H. Yamamoto, and H. Okamoto: "Gunma Symposia on Endocrinology" VNU Science Press BV, IN PRESS (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 高澤伸,山本博,井上千代子,志賀清人,寺薗公雄,北川元生,山上孝司,岡本宏: "糖尿病動物1" 医薬ジャーナル社, 305 (1987)

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      1987 Annual Research Report
  • [Publications] 寺薗公雄,山本博,高澤伸,志賀清人,米村豊,栩野義博,岡本宏: "糖尿病動物2" 医薬ジャーナル社, (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Takasawa,S.;Yamamoto,H.;Terazono,K.;Okamoto,H.: Diabetes. 35. 1178-1180 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yamamoto,H.;Nata,K.;Okamoto,H.: J.Biol.Chem.261. 6156-6159 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yanaihara,C.;Hashimoto,Y;Takeda,Y.;Kato,I.;Track,N.S.;Nokihara,K.;Manaka,H.;Iwanaga,T.;Fujitaa,T.;Okamoto,H.;Yanaihara,N.: Peptide. 7. 83-88 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yamagami,T.;Ohsawa,K.;Nishizawa,M.;Inoue,C.;Gotoh,E.;Yanaihara,N.;Yamamoto,H.;Okamoto,H.: Ann.N.Y.Acad.Sci.(1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Inoue,C.;Shiga,K.;Takasawa,S.;Kitagawa,M.;Yamamoto,H.;Okamoto,H.: Proc.Natl.Acad.Sci.U.S.A.(1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Noguchi,M.;Takahashi,K.;Okamoto,H.: J.Biol.Chem.(1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Okamoto,H.;Yamamoto,H.;Yamagami,T.;Takasawa,S.: "Diabetes 1985" Elsevier Science Publishers B.V., 524 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 山本博,高澤伸,井上千代子,志賀清人,寺薗公雄,北川元生,山上孝司,岡本宏: "遺伝子工学と医学" 東京化学同人, 250 (1987)

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      1986 Annual Research Report
  • [Publications] BioEssays. 2-1. (1985)

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      1985 Annual Research Report
  • [Publications] Biomed.Biochim.Acta. 44-1. (1985)

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      1985 Annual Research Report
  • [Publications] ADP-Ribosylation of Proteins,Springer Verlag,Berlin,Heidelberg. (1985)

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      1985 Annual Research Report
  • [Publications] Biochem.Biophys.Res.Commun.132-3. (1985)

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      1985 Annual Research Report
  • [Publications] J.Biol.Chem.261-10. (1986)

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      1985 Annual Research Report
  • [Publications] Cancer Research. 45-4. (1985)

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      1985 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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