| Project/Area Number |
60303006
|
|---|
| Research Category |
Grant-in-Aid for Co-operative Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
天然物有機化学
|
|---|
| Research Institution | TOHOKU UNIVERSITY |
|---|
Principal Investigator |
OGURA Kyozo Chemical Research Institute of Non-Aqueous Solutions, Tohoku University, 非水溶液化学研究所, 教授 (80006303)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUGA Takayuki Faculty of Science , Hiroshima University, 理学部, 教授 (00033811)
OHNO Atsuyoshi Insitute for Chemical Research, Kyoto University, 化学研究所, 助教授 (70027077)
GOTO Toshio Faculty of Agriculture, Nagoya University, 農学部, 教授 (20023369)
ITO Sho Faculty of Science, Tohoku University, 理学部, 教授 (00004242)
MASAMUNE Tadashi Faculty of Science, Hokkaido University, 理学部, 教授 (60000717)
|
|---|
| Project Period (FY) |
1985 – 1987
|
| Project Status |
Completed (Fiscal Year 1987)
|
| Budget Amount *help |
¥7,700,000 (Direct Cost: ¥7,700,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1985: ¥4,500,000 (Direct Cost: ¥4,500,000)
|
|---|
| Keywords | Natural organic compounds / Natural product chemistry / Biosynthesis / Biosynthesis of isoprenoids / Phytoalexin / luciferase / 昆虫ホルモン / 微生物還元 / 代謝物 / 立体化学 / イソプレノイド / 立体特異性 |
|---|
| Research Abstract |
(1) Metabolic pathways for rishitin, a phytoalexin of potato were clarified, and hydrogen peroxide was identified as an endogeneous elicitor of this phytoalexin. (2) The absolute stereochemistry of new prenyltransferase reactions were established. (3) Essential activation factors for undecaprenyl diphosphate synthase were isolated and identified. (4) The two essential protein components of hexaprenyl diphosphate synthase were purified and their functions were characterized. (5) Bacterial squalene synthetase was first isolated. (6) Phosphoryl derivatives of ecdysteroids were identified as conjugates in Bombyx ovaries. (7) Biosynthesis of ursolic acid from aceatate in tissue cultures of Rabdasia japonica Hara was elucidated with ^<13>C,^2H-double labeled precursors. (8) A complex consisting of luciferase and luciferin derived pigment was isolated from Cypridina. (9) Stereo- and regeo-controlled reactions with NAD(P)H models were developed. (10) Stereoselective reductions by yeast were used to prepare useful chiral synthons. (11) Acromelic acids, agelasines, and bayunol were synthesized by effective methods. (12) New terpenoids with novel strucures were isolated from marine organisms. (13) New synthetic reactions useful for biosynthetic study were developed.
Information was effectively exchanged among the members of this project to promote their research activities.
|
