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Structure and Functions of Proteins of Immunological Interest

Research Project

Project/Area Number 60303031
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 生物物性学
Research InstitutionThe University of Tokyo

Principal Investigator

ARATA Yoji  東京大学, 薬学部, 教授 (40011499)

Co-Investigator(Kenkyū-buntansha) MIZOBUCHI Kiyoshi  東京大学, 理学部, 助教授 (00092346)
UTSUMI Sayaka  愛媛大学, 医学部, 教授 (30028493)
KYOGOKU Yoshimasa  大阪大学, 蛋白質研究所, 教授 (90012632)
KUROSAWA Yoshikazu  藤田学園保健衛生大学, 医学部, 教授 (10109259)
OKUMURA KO  順天堂大学, 医学部, 教授 (50009700)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1985: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsImmunoglobulin / T-Cell Receptor / Nuclear Magnetic Resonance / 分子遺伝学 / ストップト・フロー法 / 細胞間相互作用
Research Abstract

班会議においては, 奥村〔self, nonself識別の分子機構:現時点での理解〕, 黒沢〔免疫学における分子生物学の役割:現状と今後〕, 松浦〔X線結晶解析による抗原抗体コンプレックスの構造〕, 三井「インターロイキンー2のX線結晶解析〕, 溝渕〔遺伝子の進化とタンパク質の機能〕, 中西〔ストップトフロー法による免疫担当細胞の認識と情報伝達〕についての要約があり, それぞれ極めて活発な意見の交換があった. それぞれの班員の代表的な研究成果は, 添付の資料にまとめられているが, 本班全体としての成果は
(a)大阪大学タンパク研セミナー:分子レベルにおける免疫研究の現状
昭和60年7月 大阪大学蛋白質研究所
および同セミナーおよび本研究班の研究成果をふまえて, 班員の黒沢と荒田が協同で編集した
(b)免疫の分子論的基礎
蛋白質・核酸・酵素臨時増刊 昭和61年7月(共立出版)
である.

Report

(3 results)
  • 1988 Annual Research Report
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] W.Ito;M.Nishimura;N.Sakato;H.Fujio;Y.Arata: J.Biochemistry. 102. 643-649 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Kuwana;S.Ito;F.Nagase;I.Nakashima;Y.Kurosawa: FEBS LETTERS. 219. 360-364 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Nakauchi;Y.Shinkai;K.Okumura: Proc.Natl.Acad.Sci.USA. 84. 4210-4214 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Udaka;M.Okaba;S.Utsumi: Molecular Immunology. 23. 1103-1110 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] M.kainosho;H.Nagao: Biochemistry. 26. 1068-1075 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Mizobuchi: Adv.Biophys.21. 3-18 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] 荒田洋治,黒沢良和 編: "免疫の分子論的基礎" 共立出版, 176 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] W.Ito,M.Nishimura,N.Sakato;H.Fujio; Y.Arata: J. Biochemistry. 102. 643-649 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y.Kuwana; S.Ito;F.Nagase; I.Nakashima; Y.Kurosawa: FEBS LETTERS. 219. 360-364 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H.Nakauchi;Y.Hinkai; K.Okumura: Proc.Natl.Acad.Sci.USA. 84. 4210-4214 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] K.Udaka; M.Okaba; S.Ustsumi: Molecular Immunology. 23. 1103-1110 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M.Kainosho; H.Nagao: Biochemistry. 26. 1068-1075 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] K.Mizobuchi: Dv.Biophys.21. 3-18 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 富田洋治,黒沢良和 編: "免疫の分子論的基礎" 共立出版, 176 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y.Ito, M.Nishimura, N.Sakato, H.Fujio, and Y.Arata: "A ^1H NMR Method for the Analyis of Antigen-Antibody Interactions: Binding of a Peptide Fragment of Lysozyme to Anti-Lysozyme Monoclonal Antibody" J.Biochemistry. 102. 643-69 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y.Kuwana, S.Itoh, F.Nagase, I.Nakashima, and Y.Kurosawa: "Production of the Constant Domain of Murine T-Cell Receptor -Chain in Chain in Escherichia Coli" FEBS Letters. 219. 360-364 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H.Nakauxhi, Y.Shinkai, and K.Okumura: "Molecular Cloning of Lyt-3 a Membrane Glycoprotein Marking a Subset of Mouse T Lymphocytes; Molecular Homology to Immunoglonulin and T-Cell Recepto Variable and Joining Regions" Proc.Natl.Acad.Sci. U.S.A.84. 4210-4214 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] K.Udaka, M.Okada, and S.Utsumi: "Co-operation between the Pair of C 2 Domains in Clq-Binding by Rabbit IgG" Molec.Immunology. 23. 1103-1110 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] M.Kainosho and H.Nagao: "Local Structural Features around the C-Terminal Segment of Streptomyces Subtilisin Inhibitor Studies by Carbonyl Carbon Nuclear Magnetic Resonance of Three Phenylalanyl Residues" Biochemistry. 26. 1068-1075 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Y.Arata and Y.Kurosawa: Molecular Immunology: Structure of Immunological Recognition Units. Kyoritsu Shuppan, 176 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] S.Nishihara: Molecular Immunology. 23. 285-290 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] N.Takahashi: Biochemistry. 25. 388-395 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] H.Nomoto: Eur.J.Biochem.157. 233-242 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] H.Arakawa: Biochemistry. 25. 6785-6789 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Y.Muto: Analytical Biochemistry. 159. 206-209 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] H.Kitagaki-Ogawa: Eur.J.Biochem.161. 779-785 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 荒田洋治 編: "免疫の分子論的基礎" 共立出版, 176 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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