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Paracrine secretion; its function, morphology and concept

Research Project

Project/Area Number 60304042
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionHokkaido University

Principal Investigator

KANNO Tomio  Hokkaido University, Faculty of Veterinary Medicine Prof., 獣医学部, 教授 (50009982)

Co-Investigator(Kenkyū-buntansha) YANAGISAWA Keiji  Tsurumi University, School of Dental Medicine Prof., 歯学部, 教授 (20064363)
YAMASHITA Hiroshi  University of Occupational and Environmental Health, School of Medicine Prof., 医学部, 教授 (00030841)
OTSUKA Masanori  Tokyo Medical and Dental University, Faculty of Medicine Prof., 医学部, 教授 (60013801)
HISADA Mituhiko  Hokkaido University, Faculty of Science Prof., 理学部, 教授 (70000768)
YANAIHARA Noboru  Shizuoka College of Pharmacy Prof., 薬学部, 教授 (80046250)
Project Period (FY) 1985 – 1986
Project Status Completed (Fiscal Year 1986)
Budget Amount *help
¥7,600,000 (Direct Cost: ¥7,600,000)
Fiscal Year 1986: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1985: ¥4,200,000 (Direct Cost: ¥4,200,000)
KeywordsCytochromes / Redox state / CCK-octapeptide / Non-spiking neurone / Substance P / Oxytocin / Triphosphoinositide (TPI) / 松果体
Research Abstract

Electrical stimulation of the dorsal root of the spinal cord induced parallel reduction of the cytochromes, <aa_3> , b and c+ <c_1> , which are recorded continuously on the surface of the cerebral hemisphere of the bullfrog brain. VIP nullified the cytochrome reduction. The redox effect may also be a part of the paracrine effects. (KANNO)
More than twenty analogs of CCK8 and CCK7 with a substituted glycine at position 3 or 4 were synthesized by the solution method for peptide synthesis. Among them, succinylated [D- <Trp^3> ]-CCK7 and succinylated [D- <Ala^3> ]-CCK7 were found to stimulate pancreatic exocrine secretion in anesthetized rats to almost same extent as did CCK8. (YANAIHARA)
A novel type of neurons which do not generate spike, non-spiking neurons, were found in the terminal ganglion of the crayfish central nervous system. The synaptic properties of these neurons were studied as a model for the analysis of the role of the slow potential change in the paracrine cells. (HISADA)
In … More an isolated spinal cord-tail preparation of the newborn rat, application of capsaicin to the tail evoked a slow depolarizing response of the lumbar ventral root. (OTSUKA)
The present results suggest that NA excites SON magnocellular cells through the <alpha_1> receptor, while NA inhibits PVN parvocellular cells through the <alpha_2> receptor. (YAMASHITA)
The antibody to triphosphoinositide (TPI) was made and applied to the cochlear hair cells. The result showed TPI clearly exists on the outer surface of the hair membrane. (YANAGISAWA
17 <beta> -estradiol (17 <beta> -ES) rapidly inhibited the excitability of Med-AMG neurons with a dose-response manner. (OOMURA)
Peptidergic regulation independent of adrenergic regulation plays an important role in the pineal function. (KANEKO)
Immunocytochemical studies were performed in the guinea pig small intestine. (KOBAYASHI)
Different kinds of neurons and paraneurons, as well as the structure and function of the chains formed of them were studied by combined electron-microscopic and immunohistochemical techniques. (FUJITA) Less

Report

(1 results)
  • 1986 Final Research Report Summary
  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] 菅野富夫: American Journal of Physiology. 251. C10-C16 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 斉藤敏之: Biomedical Research. 7. 437-443 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 菅野富夫: 医学と薬学. 17. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 矢内原千鶴子: Biomedical Research. 6. 111-115 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 矢内原千鶴子: Peptides. 7. 83-88 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 高畑雅一: Journal of Neurophysiology. 56. 718-731 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 近藤康弘: Journal of Comparative Neurology. 251. 334-348 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 柳沢光彦: Neuroscience Letters. 70. 278-282 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 柳沢光彦: Neuroscience Letters. 68. 351-355 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 奥屋茂: Brain Research. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 奥屋茂: Journal of Physiology. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 浅沼厚: Neuroscience Letters. 69. 249-253 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 浅沼厚: Neuroscience Letters. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 鍋倉淳一: Science. 233. 226-228 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 加来浩平: Endocrinology. 117. 2371-2375 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 加来浩平: Peptides. 7. 193-195 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 土屋満佐子: Biomedical Research. 8. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 小林繁: Archivum histologicum japonicum. 49. 159-188 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 油井龍五: Archivum Histologicum Japonicum. 49. 369-377 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 藤田恒夫: Advances in Neurological Sciences. 30. 1061-1067 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 岩永敏彦: Cell Tissue Research. 244. 565-568 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] 久田光彦: "The neuronal basis of equilibrium behaviour in decapod crustacea."Co-ordination of Motor Behaviour"" Cambridge University Press, (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Tomio Kanno: "Influence of extracellular [ <Ca^(2+)> ] on secretory and redox responses to CCK-8 in perfused rat pancreas" American Journal of Physiology. 251. C10-C16 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Toshiyuki Saito: "Vascular perfusion of ifenprodil abolishes parallel reduction of cytochromes induced by afferent electrical activation of perfused bullfrog brain" Biomedical Research. 7. 437-443 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Tomio Kanno: "Physiology of brain-gut hormones (in Japanese)" The Journal of Medicine and Pharmaceutical Science. 17. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Chizuko Yanaihara: "Dissociation of pancreozymin (PZ) activity from cholecystokinin (CCK) activity by <N^alpha> -carboxyacyl CCK7 and CCK8 analogues with a substituted glycine" Biomedical Research. 6. 111-115 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Chizuko Yanaihara: "PHI structural requirements for potentiation of glucose-induced insulin release" Peptides. 7. 83-88 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] M. Takahata: "Local nonspiking interneurons involved in gating of the descending motor pathway in crayfish" J. Neurophysiol.56. 718-731 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Y. Kondoh: "Regional specialization in synaptic input and output in an identified local non-spiking interneuron of the crayfish revealed by light and electron microscopy" J. Comp. Neurol.251. 334-348 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Mitsuhiko Yanagisawa: "Inhibitory effects of galanin on the isolated spinal cord of the newborn rat" Neuroscience Letters. 70. 278-282 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Mitsuhiko Yanagisawa: "E-type prostaglandins depolarize primary afferent neurons of the neonatal rat" Neuroscience Letters. 68. 351-355 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Shigeru Okuya: "Angiotensin <II> sensitive neurons in the supraoptic nucleus, subfornical organ and anteroventral third ventricle of rats in vitro" Brain Research. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Shigeru Okuya: "Effects of atrial natriuretic polypeptide on the rat hypothalamic neurones in vitro" Journal of Physiology. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Atsushi Asanuma: "Induction of taurine responsiveness in Xenopus oocytes by messenger RNA from mouse brain" Neuroscinece Letters. 69. 249-253 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Atsushi Asanuma: "The distribution of GABA and glycine response in the mouse brain using Xenopus oocytes" Neuroscience Letters. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Junichi Nabekura: "Mechanism of the rapid effect of 17 <beta> -estradiol on medial amyydala neurons" Science. 233. 226-228 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kohei Kaku: "Light and agonist alter vasoactive intestinal peptide binding and intracellular accumulation of adenosine 3',5'-monophosphate in the rat pineal gland" Endocrinology. 17. 2371-2375 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Kohei Kaku: "Circadian cycles in VIP content and VIP stimulation of cyclic AMP in the rat pineal gland" Peptides. 7. 193-195 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Masako Tsuchiya: "Demonstration of receptors specific for peptide N-terminal histidine and C-terminal isoleucine (PHI) using rat PHI and rat dispersed pineal cells" Biomedical Research. 8. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Shigeru Kobayashi: "Framework of the enteric nerve plexuses: an immunocytochemical study in the guinea pig jejunum using an antiserum to S-100 protein" Archivum histologicum japonicum. 49. 159-188 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Ryogo Yui: "Immunocytochemical studies on the pancreatic islets of the ratfish Chimaera monstrosa" Archivum histologicum japonicum. 49. 369-377 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Tsuneo Fujita: "Paraneuron concept and the continuity between the nervous and endocrine system" Advances in Neurological Sciences. 30. 1061-1067 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Mitsuhiko Hisada: Cambridge University Press. The neuronal basis of equilibrium behaviour in decapod crustacea. "Co-ordination of Motor Behaviour", (1985)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary
  • [Publications] Hiroshi Yamashita: Alan R. Liss. Effects of noradrenergic system on the supraoptic and paraventricular cells of mice in vitro. "Organization of the Autonomic Nervous System: central and peripheral mechanisms.", (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1986 Final Research Report Summary

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Published: 1987-03-31   Modified: 2016-04-21  

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