External perturbation and homeostasis-functional interrelation in nervous regulatory systems
| Project/Area Number |
60304045
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
環境生理学(含体力医学･栄養生理学)
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| Research Institution | Niigata University School of Medicine. |
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Principal Investigator |
NIIJIMA Akira Niigata University School of Medicine, Professor., 医学部, 教授 (20018287)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Teruo Osaka University, Faculty of Medicine, Professor., 医学部, 教授 (80022763)
SANO Yutaka Kiyoto profectural Medical clooege, President., 学長 (00079683)
SATO Akio Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Director., 部長 (60072980)
OOMURA Yutaka Kyushu University, Faculty of Medicine, Professor., 医学部, 教授 (30019517)
IRIKI Masami Yamanashi Medical College, Professor., 教授 (90072967)
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| Project Period (FY) |
1985 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥6,100,000 (Direct Cost: ¥6,100,000)
Fiscal Year 1986: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1985: ¥3,400,000 (Direct Cost: ¥3,400,000)
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| Keywords | External Perturbation / Internal Environment / Regulation / Control / Metabolism / Osmotic Pressure / Autonomic Nerve / 温度 |
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| Research Abstract |
It is known that the nervous regulatory systems play important roles for sustaining the constancy of the internal environment under external perturbation. This project was planned to analyse the input-output relationships (sensory inputs and autonomic outflows) and integrative functions of the hypothalamus in relation to regulatory mechanism of cardiovascular, thermal, metabolic, osmotic and ingestinal regulatory functions. The results of this project are as follows:
1. Control of food ingestion and metabolism. (a) Modulatory role played by intrinsic substances 2-DTA and 2-B40 in regulation of food intake and autonomic outflows through LHA neurons (Oomura). (b) Plasticity of LHA neuron activities in visual stimulation of food (Ono). (c) Integrative role played by hypothalamus on gustatory, thermal and glucoresponsive sensory imputs for autonomic outflows in regulation of metabolism (Niijima). (d) Nervous inhibitory mechanism of metabolism by neuropeptides (Nagasaka). (e) Studies on nerv
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ous pathway from central gray to hypothalamus in relation of reproduction (Sakuma).
2. Role of thermal environment in regulation of body temperature and metabolism. (a) Thermoregulatory function of PO/AH can be compensated by the other hypothalamic area after lesion (Kosaka). (b) Non-shivering heat production is controled by sympathetic efferents as well as glucagon level in the blood (Kuroshima). (c) Responsiveness of thalamic neurons for thermal and mechanical stimulation of scrotum (Nakayama). (d) Refelx effect of the adrenal efferents can be evoked by cutaneous as well as chemoreceptor stimulation (Sato). (e) Vagus nerve plays an important role in the interrelation between cardiovasular and thermal regulatory systems (Iriki).
3. Osmoreception and water balance. (a) Identification of sensory pathway from hepatic vagal osmoreceptors to PBN through NTS (Adachi). (b) Studies on osmotic and baroreceptor inputs to thermosensitive neurons in PO (Hori). (c) Regulation of PVN neurons by osmotic, thermal and peptidergic stimulations (Yamashita). (d) Role played by hypothalamus on Na-pump activity in striated muscle membrane (Akaike). (e) Immunohistochemical studies on petidergic and aminergic neurons in relation to hypothalamo-hypophyseal functions (Sano).
All of these reports brought an advancement in understanding of neural control mechanisms in homeostasis. Less
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Report
(1 results)
Research Products
(14 results)
