• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The study of mechanism of the proliferation of lymphoid tissue - The specificity of Japanese -

Research Project

Project/Area Number 60304049
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionFukushima Medical College

Principal Investigator

WAKASA Haruki  Fukushima Medical College, School of Medicine Professor, 医学部, 教授 (30004568)

Co-Investigator(Kenkyū-buntansha) SUCHI Taizan  Aichi Cancer Center Hospital Chairman, 部長 (30163033)
KIKUCHI Masahiro  Fukuoka University, School of Medicine Professor, 医学部, 教授 (80078774)
IMAI Yutaka  Yamagata University, School of Medicine Professor, 医学部, 教授 (30045603)
MIKATA Atsuo  Chiba University, School of Medicine Professor, 医学部, 教授 (40051289)
HANAOKA Masao  Kyoto University, Virus Research Institute Professor, ウィルス研究所, 教授 (30027304)
白川 茂  三重大学, 医学部, 教授 (20026850)
森 尚義  筑波大学, 基礎医学系, 講師 (90045732)
石川 栄世  東京慈恵会医科大学, 医学部, 教授 (00056441)
森 茂郎  東京大学, 医科学研究所, 教授 (30010424)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 1987: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1986: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1985: ¥4,700,000 (Direct Cost: ¥4,700,000)
KeywordsKimura's disease / Reticular lymphocyte / Necrotizing lymphadenitis / Follicular dendric cell / Tl^+ / Tac^+ lymphocyte / AILD / RLH / Tリンパ球 / Tac陽性Bリンパ球 / 日和見リンパ腫
Research Abstract

In order to elucidate the mechanism of the proliferation of lymphoid tissue, the research group studied not only from the view point of the morphology and function of component cells but clinicopathological appraisal.
1).Fundamental investigation: a). T lymphocytes; Monoclonal antibody of cytotoxic T lymphocyte(CTL) clone was especially effective for glioma cells, and another monoclonal antibody specific for Langerhans granules was also prepared. It was suggested by immunoelectron microscope that Leu 4 antigen appearance in T cell lymphoma was dependent on the step of tumor cell differentiation. b). B lymphocytes: Reticular lymphocytes (RL) focus is the differentiation and proliferation area of B lymphocytes. B lymphocytes cultured from peripheral blood showed a change to dendritic reticular cells, it was not clear to define relation to dritic reticulum cell or interdigitating reticulum cells(IDC). Tl+ and Tac+ cells existed in the outer zone of mantle zone of germinal center.
2).Reactiv … More e Disorders; IDCs and Langerhans cells were characterized by the positivity for Leu 6, S 100 protein and Ia antigens and it was suggested that T lymphocytes had an intimate communication to these cells. In necrotizing lymphadenitis, hematological analysis revealed a high value of HLA-DR52 positivity, and a correlation between clinical course and Leu 3a/2a ratio. Ig E Fc receptor positive cells coincided with lymphocytes and dendritic reticulum cells within germinal centers in Kimura's disease. Angioimmunoblastic lymphadenopathy was characterized by the proliferation of Ia+T4+ and on the other hand, in in infectious mononucleousis the destruction of T8+ lymphocytes was characteristically observed. In AIDS, B cell in the lymph nodes showed dysfunction as a result of destruction of follicular dendritic cells by an infection of HIV. Lymphadenopathy with SLE rately often progressed to extranodal malignant lymphoma composed from diffuse proliferation of large tumor cells. Gastric lymphoma originated from reactive lymphoid hyperplasia (RLH) showed gradual progression with medium or mixed type of lymphoma cells comparing with other type of malignant lymphoma occurred from the stomach without RLH. Less

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report

Research Products

(37 results)

All Other

All Publications (37 results)

  • [Publications] Asano S.; Muramatsu T.; Kanno H. & Wakasa H.: Acta Pathol. Jpn.37. 887-900 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Asano S.; Kanno H.; Tominaga K.; Muramatsu T.; Nozawa Y.; Akaike Y.; Segami H. & Wakasa H.: Acta Pathol. Jpn.37. 1071-1084 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 浅野重之.若狭治毅: 臨床科学. 23. 1316-1323 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 浅野重之.赤池康.陣内弘和.村松尚夫.若狭治毅.吉田博.近藤康平.小島勝.城下尚: 病理と臨床. 6. IN PRESS (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三方淳男.鈴木浩: 臨床免疫. 19. 176-182 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Horiguchi Y., Kashihara M., Fukukawa F., Oh SH, Ueda M., Hanaoka M. & Imamura S.: Acta Histochem. Cytochem.119. 305-315 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Imai Y., et al.: Histol. Histopath.1. 19-26 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Mori S. & Sugiyama S.: Acta Hematol. Jpn.50. 1652-1656 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Namikawa R.; Suchi T.; Ueda R.; Itoh T.; Koike K.; Ota K. & Takahashi T.: Am. J. Pathol.127. 279-287 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 北堅吉,白川茂,他: Medical Immunology. 14. 1 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 難波紘二,若狭治毅.飯島宗一.他 編: "現代病理学大系18B (血液造血器2) 悪性リンパ腫の地理病理学" 中山書店, 438 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 三方淳男,飯島宗一,他 編: "現代病理学大系 18B (血液造血器2) リンパ節の構造と機能" 中山書店, 438 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 須知泰山,飯島宗一,他 編: "現代病理学大系18B (血液造血器2) リンパ増殖性疾患" 中山書店, 438 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Asano S., Muramatsu T., Kanno H. & Wakasa H.: "Dermatopathic lymphadenopathy. Electronmicroscopic, enzyme-histochemical and immunohistochemical study." Acta Pathol. Jpn.37. 887-900 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Asano S., Kanno H., Tominaga K., Muramatsu T., Nozawa Y., Akaike Y., Segami H. & Wakasa H.: "Necrotizing lymphadenitis. Electron microscopic and immunohistochemical study." Acta Pathol. Jpn.37. 1071-1084 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Asano S. & Wakasa H.: "Pathological features of lymphoreticular tissue in human HIV infection." J. Clin. Sci.23. 1316-1323 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Asano S., Akaike Y., Jinnouchi H., Muramatsu T., Wakasa H., Yoshida H., Kondou R., Kojima M., & Joshita T.: "Necrotizing lymphadenitis. 4 familial cases and 4 a recurrent cases." Pathology and Clinics. 6. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Mikata A. & Suzuki H.: "Immunohistochemical analysis of stromal cell reaction against B-lymphomas." Clin. Immunol.19(Supple.). 176-182 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Horiguchi Y., Kashihara M., Fukukawa F., Oh SH, Ueda M., Hanaoka M. & Imamura S.: "Monoclonal antibody of human skin basal cells - Immunoelectron microscopic studied on tissue specific cross - reactivity." Acta Histochem. Cytochem.119. 305-315 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Imai Y., et al.: "Postnatal development of dendritic reticulum cells and their immune complex trapping ability" Histol. Histopath.1. 19-26 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Mori S. & Sugiyama S.: "Angioimmunoblastic lymphadenopathy with dysproteinemia. Its position in T cell proliferative disorders." Acta Haematol. Jpn.50. 1652-1656 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Namikawa R., Suchi T., Ueda R., Itoh G., Koike K., Ota K. & Takahashi T.: "Phenotyping of proliferating lymphocytes in angioimmunoblastic lymphadenopathy and related lesions by double immunoenzymatic staining technique." Am. J. Pathol.127. 279-287 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kita K., Shirakawa S., et al.: "Angioimmunoblastic lymphadenopathy" Medical Immunology. 14. 1 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Nanba K. & Wakasa H.: Geographic Pathology of Malignant lymphoma in:Current Encyclopedia of Pathology 18B (Blood and Hematopoietic Organ II). Ed. by Iijima, S. Nakayama Shoten, 438 (153-182) (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Suchi T.: Lymphoroliferative Disease in: Current Encyclopedia of Pathology 18B (Blood and Hematopoietic Organ II). Ed. by Iijima, S. Nakayama Shoten, 438 (139-152) (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Asano S;Wakasa H.: Fukushima J.Med.Sci.31. 71-78 (1985)

    • Related Report
      1986 Annual Research Report
  • [Publications] 浅野重之,若狭治毅: 福島医誌. 35. 325-335 (1985)

    • Related Report
      1986 Annual Research Report
  • [Publications] Kohno M;Kuwata S;Namba Y;Hanaoka M.: FEBS Letters. 198. 33-37 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Horiguchi Y;Kashihara M;Fukukawa F;Oh SH;Ueda M;Hanaoka M;Imamura S.: Acta Histochem.Cytochem.119. 305-315 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 三方淳男: 病理と臨床. 4. 506-513 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 三方淳男: 逓信医学. 38. 447-451 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Kikuchi M;Takeshita M;Tashiro K;Mitsui T;Eimoto T;Okamura S.: Virchows Arch.(Pathol.Anat.). 409. 299-311 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Oka K;Mori N;Kojima M;Miyamoto T.: Am.J.Clin.Pathol.86. 220-224 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Nakazawa M;Ninomiya H;Abe T;Mori N;Kojima M.: Acta Haematol.Jpn.49. 938-949 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 白川茂,北堅吉,三輪啓志: Immuno-Advance. 14. 136-143 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Miwa H;Kita K;Ohmo T;Tanaka I;Shirakawa S;Doi S;Kamesaki H;Honjo T;Hatanaka M.: Acta Haematol.Jpn.49. 1188-1193 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Namikawa R;Suchi T;Ueda R;Itoh G;Koike K;Ota K;Takahashi T.: Amer.J.Pathol.(1987)

    • Related Report
      1986 Annual Research Report

URL: 

Published: 1987-03-30   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi