• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of early treatments for acute myocardial infarction: Basic and co-operative studies

Research Project

Project/Area Number 60304061
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

NAKAMURA Motoomi  Kyushu University, Faculty of Medicine, Professor, 医学部, 教授 (60037322)

Co-Investigator(Kenkyū-buntansha) 中村 芳郎  慶応大学, 医学部, 助教授 (40051221)
YAZAKI Yoshio  Tokyo University , Faculty of Medicine, Lecturer, 医学部, 講師 (20101090)
SUGIMOTO Tsuneaki  Tokyo University , Faculty of Medicine, Professor, 医学部, 教授 (60019883)
ABIKO Yasushi  Asahikawa Ika University, Faculty of Medicine, Professor, 教授 (90041821)
HOSODA Saichi  Jichi Ika University , Professor, 教授 (50048956)
NAKAMURA Yoshiro  Keio Gijuku University ,Faculty of Medicine, Associate Professor (60037322)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥28,800,000 (Direct Cost: ¥28,800,000)
Fiscal Year 1987: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1986: ¥9,800,000 (Direct Cost: ¥9,800,000)
Fiscal Year 1985: ¥17,100,000 (Direct Cost: ¥17,100,000)
Keywordsacute myocardial infarction / reperfusion / energy metabolism / arrhythmia / infarct size / cardiac function / アラキドン酸代謝産物 / 心室細動閾値 / 心筋壊死 / 心筋PH / 右室梗塞 / 【^(31)P】-NMR
Research Abstract

1. Strateqies of the research group; Effectiveness and salutatory mechanism of the early treatment of acute myocardial infarction were studied experimentally in 10 institutions in Japan. The research projects of the group were constituted from both a cooperative study on the effects of reperfusion for tissue salvage from myocardial necrosis and independent studies relating to myocardial ischemia. The goal of the present study was 1) to elucidate the factors which determine the irreversible damage of the myocardium after ischemic insult, 2) to derive useful indexes representing sensitively the alterations of myocardial reversibility and 3) to establish the remedies to reduce myocardial necrosis.
2. Co-operative study on the effects of reperfusion on ischemic myocardium ; Alterations of energy metabolism in vivo during myocardial ischemia or hypoxemia were determined spectrologically by NMR and early changes of intracellular pH were demonstrated (Imai, Hosoda). Effects of reperfusion on regional wall motion, incidnce of fatal arrhythmia, and intramyocardial pH after 3 hours of coronary occlusion were examined in anesthetized canine model using two dimensional echocardiography (Yazaki) or cardiomovegraphy (Tamura), electrophysiology (Sugimoto) and implantable pH sensors (Abiko), in which the level of wall motion and the size of myocardial necrosis or the amount of myosin light-chain kinase released was discordant early after reperfusion. A significant tissue salvage in a reperfusion group 24 hours after 90 minutes (Nakamura M) but not 3 hours (Nakamura Y) of coronary occlusion was demonstrated in a canine model. Shibata demonstrated some beneficial effects of a lipoxigenase antagonist on tissue salvage against reperfusion damage.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Nakamura,M.: Circulation. 75. 1110-1116 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Isobe,M.: Circulation. 74(SUPPL). 1040 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Isobe, M: Circulation.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ochi, S.: Journal of Cardiovascular Pharmacology.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Toyooka, T.: Biochemical and Biophysical Research Communications. 135. 808-815 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Toyooka, T.: Biochemical and Biophysical Ressearch Communications. 144. 841-848 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Nakamura, M.: "Cardiovascular desease: Molecular and cellular mechanisms, prevention and treatment." Plenum Pub. Corp., New York, 365-368 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Imai, S.: "Energy metablism in ischemic myocardium: A NMR study Shoich Imai Regulation of cardiac function." Japan Sci. Press, Tokyo/VNU Sci.Press Utrecht, 153-160 (1984)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Nakamura M.: "Clinical characteristics associated with myocardial infarction, arrhythmias and sudden death in patients with vasospastic angina." Circulation. 75. 1110-1116 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Isobe M.: "Quantitative assessment of the effects of coronary reperfusion by serum cardiac myosin light chain in conscious dogs." Circulation. 74(Supple). 1040- (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Isobe M.: "Quantitative relationship between left ventricular function and serum cardiac myosin light chain I levels after coronary -reperfusion in patients with acute myocardial infarction" Circulation.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ochi, S.: "Effects of -Blockers on the fall of pH in the early phase of ischemia in the isolated perfused rat heart: a Nuclear magnetic resonance study." Journal of Cardiovascular pharmacology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Toyooka, T.: "Rhythmic change of myocardial phosphate metabolite content in cardiac cycle observed by depth-selected and EKG-Gated in vivo^<31>P-NMR spectroscopy in a whole animal." Biochemical and Biophysical Research Communications. 135. 808-815 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Nakamura, M.: Cardivascular disease: Molecular and cellular mechanisms, prevention and treatment. Plenum Pub. Corp., New York, 365-368 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Ohzono,K.: Circulation Research. 59(1). 63-73 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Abiko,Y.;Fukushi,Y.;Haga,N.;Matumura,H.: Brirish Journal of Pharmacology. 87. 427-432 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 豊岡照彦,細田瑳一,他: Biochemical and biophysical research communications. 135. 808-815 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Issei,Komuro;et al.: Jouxcal.of Biological Chemistry. 261. 4504-4509 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Nakazawa,M.;Ochi,S.;Ogawa,Y.;Imai,H.and Imai,S.: Japanese Journal of Pharmacology. 43. 13 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 住吉昭信,浅田祐士郎,林透: Therapeutic Research. 6. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 中村元臣,平則夫,編: "カルシウム拮抗薬-基礎と臨床第2章【Ca^(2+)】拮抗薬の血管平滑筋に対する作用" 医薬ジャーナル社, 365 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 柴田宣彦,赤神宏尚,三摩秀之: "Siomedieal and clincal Aspects of Coenzyme Q.vol.5 (Eds.K.Folkers and Y.Yamamura);Increase of 12-hydrozyeicosatetraenoid acid in experimental ischemie myocardium and an effects of coenzyme【Q_(10)】on the phenomena P179-190" Elsevier Science Publishers Amsterdam New York Oxford, 11(410) (1986)

    • Related Report
      1986 Annual Research Report

URL: 

Published: 1987-03-31   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi