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Disturbance of Integral of Cerebral Hemispheres in Fuvctional Psychoses

Research Project

Project/Area Number 60304063
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAKAHASHI Ryo  Tokyo Medical and Dental University Department of Newropsychiatry,Faculty of Medicine・Professor, 医学部, 教授 (70009918)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Saburo  Shiga University, Department of Neuropaychiatry,Faculty ofMedicine.Professor, 精神医学講座, 教授 (20079916)
NIWA Shin-ichi  University of Tokyo, Department of Neuropsychiatry,Facultyof Medicine.Assisant, 医学部精神医学教室, 助手 (30110703)
HOSAKI Hideo  Keio University, School of Medicine, Department of Neuropsychiatry.Professor, 医学部精神神経科, 教授 (30051056)
MACHIYAMA Yukiteru  Gunma University, Department of Neuropsychiatry,Faculty ofMedicine.Professor, 医学部神経精神医学教室, 教授 (40010194)
大熊 輝雄  国立精神, 神経センター武蔵病院, 院長
OOKUMA Teruo  National Musashi Research Institute for Mental and Nervous Diseases Presiclent
稲永 和豊  久留米大学, 医学部, 教授 (00080705)
山口 成良  金沢大学, 医学部, 教授 (00064501)
Project Period (FY) 1985 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 1987: ¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 1986: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1985: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsFunctional Psychoses / Integral Function of Cerebral Hemispheres / Neuropsychology / Eye Movements / Event-relsted Potential / CNV / Regional Blood Flow / MRI-CT / 脳局所血流 / 核磁気共鳴脳断層撮影 / 精神分裂病
Research Abstract

DISTURBANCE OF INTEGRAL FUNCTION OF CEREBRAL HEMISPHERES IN FUNCTIONAL PSYCHOSES This project was conducted to clarify the disturbance of differential and integral functions of the cerebral hemisperse in functional psychoses using multi-dimentional methods. The relationships between right and left hemispheres as well as cortical and subcortical areas, and frontal and posterior regions were explored using neurophysiologicsl, psychophysiological, neuropsychological and morphological methods. Dr.Torii,H. explored the mirror writing and age desorientation in schizophrenia, Dr.Hozaki,H. distinguished schizophrenics from patients with frontal lobe lesion using the new modified Wisconsin Card Sorting Test.Dr.Okuma,T. showed the cerebral lateralization in functional psychosis measured by horizontal eye movements, Dr.Takahashi,R. examined the relationship between clinical symptoms and the tempo measuted by eye movements and he also studied the cerebral lateralization of eye fixations and moveme … More nts in temporal lobe spilepsy compared to focal sides of spikes.Dr.Takahashi, S. sutdied the interhemispheric dysgunction on verbal tasks in schizophrenia using CNV. Dr.Niwa showed event-related potential correlates of psychotropic drug effects on attentional and hemispheric dysfunction in schizophrenia. Dr.Machiyama,Y. also studied the event-related potential to clarify the topographic and temporal aspects of information processing abnormalities in schizophrenia. Dr.Yamaguchi,N.examined the regional blood flow in schizophrenics and depressed patients.Dr.Inanaga,K. examined morphological changes in the brains of schizophrenics using MRI-CT. From the view point of right and left hemispheric functions,most of our studies suggested thst schizophrenics had a left hemispheric dysfunction rather than the right one. The neurophysiological report suggested that the predominant side of cerebral hemispheric function was changeable according to the prognosis or types of schizophrenia such as a paranoid and a non-paranoid. Although the hypofrontality theory of schizophrenia is prevalent, the results obtained in our project were not consistent with the theory and suggested not only frontal lobe but aiso the other regions such as limbic system, thalamic muclei and basal ganglia may be involved to produce a schizophrenia.These collaborative studies had been done for 3 yesrd was very fruitful for the clarification of pathophysiological mechanism of schizophrenia. Less

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Kojima,T.: Psychopharmacology Bulletin. 22. 768-773 (19868)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Matsue,Y.: Biolobical Psychiatry. 21. 382-389 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 鹿島 晴雄: 神経研究の進歩. 30. 847-858 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] John H. Gruzelier: 精神医学. 29. 1024-1031.1138-1146 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 佐藤 洋子: 悩波と筋電図. 15. 58-68 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 玉井 顕: 精神医学. 27. 1439-1442 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takanashi, R.: "Cerebral Dynamids,Laterality and Psychopathology" Elsevier, 588 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kojima, T.: "Uisual Percepticn Process in Amphetamine Psychosis and Schizophrenic" Psychopharmacology Bulletin. 22. 768-773 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Matsue, Y.: "Saccadic Eye Movements in Tracking,Fixation,and Rest in Schizophrenic and Nornal Subjects." 21. 382-389 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kashima, H.: "Disorders of attenticn due to grontal lobe lesion." Advances in Neurological Sciences. 30. 847-858 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] John H.Gruzelier: "Hemispheic Imbalance in Dynamic Processes : An important indiidual difference in the normal and pathological brain (I) (II)" Clinical Psychiatry. 29. 1024-1031 1138-1146 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Sato, Y: "Interhemispheric difference of CNV waveform on verbal task: Halthy controland schizophrenia" Jpn J EEG EMG. 15. 58-68 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takahashi, R.: Cerebral Dynamics,Laterality and Psychopathology. Elsevier, 588 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Takuya Kojima;Ryo Takahashi;et al.: Psychopharmacology Bulletin. 22. 768-773 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 斉藤治,丹羽真一 他: 神経進歩. 30. 827-840 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Yoshihiko Matsue;Teruo Okuma et al.: Biol Psychiatry. 21. 382-389 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 丹野義彦,町山幸輝: 臨床精神医学. 15. 53-62 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 高橋三郎 他: 精神医学. 28. 1163-1172 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 倉知正佳,山口成良 他: 臨床精神医学. 16. 75-82 (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Ryo Takahashi,Shin-ichi Niwa et al.: "Cerebral Dynamics,Laterality and Psychopathology" Elsevier, (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] 稲永和豊,融道男: "続・分裂病とは何か" 東大出版会, (1987)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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