| Project/Area Number |
60304070
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | Kagawa Medical School |
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Principal Investigator |
OGULI Kenji Kagawa Medical School, Professor, 医学部, 教授 (40079934)
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| Co-Investigator(Kenkyū-buntansha) |
KANESHINA Shoji Kyushu University, College of General Education,Professor, 教養部, 教授 (80035617)
TERADA Hiroshi Tokushima University, Faculty of Pharmaceutical Science, Professor, 薬学部, 教授 (00035544)
SHIRAHAMA Keishiro Saga University,Faculty of Science & Engineering, Professor, 理工学部, 教授 (50039252)
SUEZAKI Yukio Saga Medical School, Professor, 医学部, 教授 (80069484)
YOSHIYA Ikuto Osaka University Medical School, Professor, 医学部, 教授 (80028505)
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| Project Period (FY) |
1985 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1987: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1986: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1985: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | Volatile anesthetics / Non-specific binding / Atypical Langmuir adsorption / Pressure reversal / Membrane boundary / 界面水和 / 麻酔機序 / モデル膜 / 生体膜 / 膜界面現象 / 麻酔の圧拮抗 |
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| Research Abstract |
On the molecular site of volatile anesthetic action, discussions were concentrated from the several points of view in the annual open conference on the mechanism of anesthesia, and in the annual closed shop meeting constituted from 14 investigators who have engaged in the fundamental study on anesthetic action. The concrete themes discussed were those ; on the membrane which is useful for thestudy on the mechanism, on the changes of charge and hydration in the phase boundary of membrane, and on the compression study and partition of ansthetics in the membrane and the membrane boundary.
Through these dosciussion, we approached to the common opinion that the binding of volatile anesthetics to action site is of non-specific type, even though the report that there is a saturable binding site related to anesthesia was presented ( Evers,A.S. et al.:Nature 328,157-160,1987 ). Saturable binding mode is seen in atypical Langmuir adsorption of volatile anesthetics which is non-specific.
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